{"id":21,"date":"2018-06-06T08:27:59","date_gmt":"2018-06-06T12:27:59","guid":{"rendered":"http:\/\/www.personal-site.dev\/?page_id=21"},"modified":"2025-03-24T03:07:24","modified_gmt":"2025-03-24T07:07:24","slug":"projects","status":"publish","type":"page","link":"https:\/\/www2.whoi.edu\/site\/hahnlab\/projects\/","title":{"rendered":"Projects"},"content":{"rendered":"\n\n\t

Projects<\/h1>\n\t

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Gene-Environment Interactions in Congenital Heart Disease<\/a><\/h3>\n

We are using the Atlantic killifish population-based model system to elucidate the interaction of genetic variation and environmental exposures in the etiology of congenital heart disease.<\/p>\n\t

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Mechanisms Controlling Sensitivity and Resistance to Dioxin-like Compounds: Role of AIP<\/a><\/h3>\n

We are investigating the role of AIP and its sequence variants in controlling sensitivity to chemicals that act through the AHR. This project includes complementary studies involving zebrafish in vivo<\/em> and human cells in vitro.<\/em><\/p>\n\t

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Oceans and Human Health: <\/a><\/h3>\n

Harmful Algal Bloom (HAB) Toxins<\/a><\/h3>\n

In this project we are investigating the neurodevelopmental toxicity of harmful algal bloom toxins such as domoic acid (DA) and saxitoxin (STX).<\/p>\n\t

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Adaptation to Pollutants: <\/a><\/h3>\n

PCB-Resistant Fish<\/a><\/h3>\n

The goal of this research is to understand the genetic mechanisms of evolved resistance to toxic chemicals in fish living in highly contaminated sites.<\/p>\n\t

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Evolution of aryl hydrocarbon receptor (AHR) <\/a>ligand specificity<\/a><\/h3>\n

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We are investigating the evolutionary trajectory and genetic and structural mechanisms underlying the evolution of AHR ligand-specificity. We are using ancestral sequence reconstruction (ASR) to “resurrect” ancestral AHR proteins and then determine their ligand-binding properties.<\/p>\n\t\n

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Marine Microplastics and Nanoplastics<\/a><\/h3>\n

Several projects address the fate and impacts of microplastics and nanoplastics in the marine environment.<\/p>\n\t

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Aryl Hydrocarbon Receptor Biology<\/a><\/h3>\n

We are studying the evolution of AHR, a protein involved in the mechanism of toxicity of a variety of synthetic and natural compounds.<\/p>\n\t

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Marine Natural Products<\/a><\/h3>\n

We are investigating the biological activity, including possible toxicity, of halogenated marine natural products.<\/p>\n\t

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Mechanisms of Embryo Response to Oxidative Stress<\/a><\/h3>\n

The goal of this research is to to elucidate the mechanisms by which vertebrate embryos respond to oxidative stress during development. We use zebrafish as a model system.<\/p>\n\n","protected":false},"excerpt":{"rendered":"

Projects Gene-Environment Interactions in Congenital Heart Disease We are using the Atlantic killifish population-based model system to elucidate the interaction of genetic variation and environmental exposures in the etiology of congenital heart disease. Mechanisms Controlling Sensitivity and Resistance to Dioxin-like Compounds: Role of AIP We are investigating the role of AIP and its sequence variants…<\/p>\n","protected":false},"author":31,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www2.whoi.edu\/site\/hahnlab\/wp-json\/wp\/v2\/pages\/21"}],"collection":[{"href":"https:\/\/www2.whoi.edu\/site\/hahnlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www2.whoi.edu\/site\/hahnlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www2.whoi.edu\/site\/hahnlab\/wp-json\/wp\/v2\/users\/31"}],"replies":[{"embeddable":true,"href":"https:\/\/www2.whoi.edu\/site\/hahnlab\/wp-json\/wp\/v2\/comments?post=21"}],"version-history":[{"count":3,"href":"https:\/\/www2.whoi.edu\/site\/hahnlab\/wp-json\/wp\/v2\/pages\/21\/revisions"}],"predecessor-version":[{"id":1239,"href":"https:\/\/www2.whoi.edu\/site\/hahnlab\/wp-json\/wp\/v2\/pages\/21\/revisions\/1239"}],"wp:attachment":[{"href":"https:\/\/www2.whoi.edu\/site\/hahnlab\/wp-json\/wp\/v2\/media?parent=21"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}