{"id":743,"date":"2025-04-16T12:53:23","date_gmt":"2025-04-16T16:53:23","guid":{"rendered":"https:\/\/www2.whoi.edu\/site\/saito-lab\/?page_id=743"},"modified":"2025-12-08T09:04:06","modified_gmt":"2025-12-08T13:04:06","slug":"homepage","status":"publish","type":"page","link":"https:\/\/www2.whoi.edu\/site\/saito-lab\/","title":{"rendered":"Homepage"},"content":{"rendered":"\n\n\t<h1>Understanding Microbial Dynamics through Bioinorganic Chemistry and Proteomics<\/h1>\n\t<p>In the Saito laboratory, we delve into the critical roles of metals and proteins in microbial life. We develop innovative approaches to understanding the metallome and proteome of environmental microbes and pathogens, to deepen our understanding of how microbial processes affect biogeochemical cycles and human health.<\/p>\n<h2>\n\t\tFeatured Projects\n\t<\/h2>\n\t\t\t\t<a href=\"https:\/\/www2.whoi.edu\/site\/saito-lab\/understanding-metal-use-in-life\/\" target=\"_self\" rel=\"noopener\">\n\t\t\t\t<img loading=\"lazy\" src=\"https:\/\/www2.whoi.edu\/site\/saito-lab\/wp-content\/uploads\/sites\/58\/2025\/04\/Fe_metallome.jpg\" alt=\"FE metallome\" height=\"382\" width=\"382\" title=\"Fe_metallome\" \/>\n\t\t\t\t<\/a>\n\t<h3><a href=\"https:\/\/www2.whoi.edu\/site\/saito-lab\/understanding-metal-use-in-life\/\">The Critical Role of Micronutrients in Life<\/a><\/h3>\n\t\t\t\t<a href=\"https:\/\/www2.whoi.edu\/site\/saito-lab\/research\/diagnosing-microbes-and-microbiomes\/\" target=\"_self\" rel=\"noopener\">\n\t\t\t\t<img loading=\"lazy\" src=\"https:\/\/www2.whoi.edu\/site\/saito-lab\/wp-content\/uploads\/sites\/58\/2025\/04\/microbes.jpg\" alt=\"microbe\" height=\"1000\" width=\"1000\" title=\"microbes\" \/>\n\t\t\t\t<\/a>\n\t<h3><a href=\"https:\/\/www2.whoi.edu\/site\/saito-lab\/research\/diagnosing-microbes-and-microbiomes\/\">Microbial Diagnosis and Activity<\/a><\/h3>\n\t\t\t\t<a href=\"https:\/\/www2.whoi.edu\/site\/saito-lab\/research\/trace-element-and-micronutrient-biogeochemistry\/\" target=\"_self\" rel=\"noopener\">\n\t\t\t\t<img loading=\"lazy\" src=\"https:\/\/www2.whoi.edu\/site\/saito-lab\/wp-content\/uploads\/sites\/58\/2025\/04\/iceberg.jpg\" alt=\"iceberg\" height=\"1000\" width=\"1000\" title=\"iceberg\" \/>\n\t\t\t\t<\/a>\n\t<h3><a href=\"https:\/\/www2.whoi.edu\/site\/saito-lab\/research\/trace-element-and-micronutrient-biogeochemistry\/\">Trace Metal Biogeochemistry from the Tropics to Antarctica<\/a><\/h3>\n<h2>\n\t\tSelected Research Highlights and Discoveries\n\t<\/h2>\n\t<p><a href=\"https:\/\/www.pnas.org\/doi\/abs\/10.1073\/pnas.1201731109\">A novel membrane B12 binding protein in marine diatoms<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/435042a\">The protein sequence of the cadmium carbonic anhydrase, the only biological function of cadmium<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-022-29603-y\">Identification and characterization of two zinc responsive proteins in marine diatoms<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41564-021-01028-1\">An explanation for daytime nitrogen fixation in Trichodesmium<\/a><\/p>\n<p><a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.jproteome.1c00517\">RNA-Protein correlations<\/a> and why they occur in microbial stress biomarkers<\/p>\n<p>The metalloproteomes of <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.01.15.633287v2.abstract\">Pseudomonas<\/a> and Pseudoalteromonas (<a href=\"https:\/\/academic.oup.com\/metallomics\/article\/12\/5\/654\/5961811\">Fe<\/a> and <a href=\"https:\/\/academic.oup.com\/metallomics\/article\/13\/12\/mfab060\/6409836\">Zn, Ni, Mn, and Co<\/a>).<\/p>\n<p><a href=\"https:\/\/www.science.org\/doi\/full\/10.1126\/science.1256450\">Detection of multiple limitations in the Central Pacific by Metaproteomics<\/a><\/p>\n<p><a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(19)33493-3\/fulltext\">The lack of iron requirement in Borrelia burgdorferi<\/a><\/p>\n\t<p><a href=\"https:\/\/www.pnas.org\/doi\/abs\/10.1073\/pnas.1006943108\">Hotbunking of iron in the unicellular nitrogen fixer Crocosphaera<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41561-020-0565-6\">Nitrite oxidoreductase, one of the most abundant metalloproteins on Earth, and calculating rates from omics<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0020169303004420?casa_token=TT2D-RiXleQAAAAA:uhUDDa_Kek927SHbv38QcU-ezX-a336dx-FiZa9ao6QGP72_5dy7xcVNAcOr5YhuaDWhHBNVjz_x\">The evolution of trace metal requirements at the Archaean Proterozoic boundary<\/a><\/p>\n<p><a href=\"https:\/\/aslopubs.onlinelibrary.wiley.com\/doi\/abs\/10.4319\/lo.2008.53.1.0276\">The Concept of Colimitation<\/a><\/p>\n<p><a href=\"https:\/\/aslopubs.onlinelibrary.wiley.com\/doi\/abs\/10.4319\/lo.2007.52.3.1079\">B12 and iron colimitation in the Ross Sea<\/a><\/p>\n<p><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.11.05.565706v2.abstract\">Evidence for the Zinc hypothesis, Carbon, and iron colimitation in coastal Antarctica<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41564-020-00814-7\">Dinoflagellates metaproteomes of the Pacific Ocean<\/a><\/p>\n<p><a href=\"https:\/\/www.pnas.org\/doi\/abs\/10.1073\/pnas.2200014119\">Microbial enzymes and functional diversity across biogeochemical provinces<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/ngeo1893\">A 1500km hydrothermal plume of iron in the South Atlantic Ocean<\/a><\/p>\n<h2>\n\t\tWant to join the Saito Lab?\n\t<\/h2>\n\t<p>Get in touch about opportunities to our group.<\/p>\n\t\t\t<a href=\"mailto:msaito@whoi.edu\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tFind out more\n\t\t\t\t\t<\/a>\n\n","protected":false},"excerpt":{"rendered":"<p>Understanding Microbial Dynamics through Bioinorganic Chemistry and Proteomics In the Saito laboratory, we delve into the critical roles of metals and proteins in microbial life. We develop innovative approaches to understanding the metallome and proteome of environmental microbes and pathogens, to deepen our understanding of how microbial processes affect biogeochemical cycles and human health. Featured&hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www2.whoi.edu\/site\/saito-lab\/wp-json\/wp\/v2\/pages\/743"}],"collection":[{"href":"https:\/\/www2.whoi.edu\/site\/saito-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www2.whoi.edu\/site\/saito-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www2.whoi.edu\/site\/saito-lab\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www2.whoi.edu\/site\/saito-lab\/wp-json\/wp\/v2\/comments?post=743"}],"version-history":[{"count":3,"href":"https:\/\/www2.whoi.edu\/site\/saito-lab\/wp-json\/wp\/v2\/pages\/743\/revisions"}],"predecessor-version":[{"id":793,"href":"https:\/\/www2.whoi.edu\/site\/saito-lab\/wp-json\/wp\/v2\/pages\/743\/revisions\/793"}],"wp:attachment":[{"href":"https:\/\/www2.whoi.edu\/site\/saito-lab\/wp-json\/wp\/v2\/media?parent=743"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}