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Google Scholar Link  and PubMed Link for the Saito Laboratory

 PAPERS IN REFEREED JOURNALS (*Ph.D. Advisee, +Post-Doc Advisees)


Walworth#, N.G., Saito, M.A.#, Lee, M.D., McIlvin, M.R., Moran, D.M., Kellogg*, R.M., Fu, F.X. and Hutchins, D.A., 2021. Why Environmental Biomarkers Work: Transcriptome-Proteome Correlations and Modeling of Multi-Stressor Experiments in the Marine Bacterium Trichodesmium.  # co-first authors. In Press at Journal of Proteome Research.

Zhou Liang, Kelly McCabe, Sarah E. Fawcett, Heather J. Forrer, Catherine Jeandel, Dario Marconi, Hélène Planquette, Mak A. Saito, Jill A. Sohm, Rachel K. Thomas, Eric A. Webb, Robert T. Letscher, Angela N. Knapp.A global ocean dissolved organic phosphorus (DOP) concentration database (DOPv2021). Submitted.

Noelle A. Held*, John B. Waterbury, Eric A. Webb, Riss M. Kellogg*, Matthew R. McIlvin, Michael Jakuba, Frederica W. Valois, Dawn M. Moran, Kevin M. Sutherland, Mak A. Saito. Dynamic diel proteome and daytime nitrogenase activity supports buoyancy in Trichodesmium erythraeum. In press at Nature Microbiology.

Kellogg*, Riss M., Dawn M. Moran, Matthew R. McIlvin, Adam Subhas, Andrew Allen, Mak A. Saito. Lack of a Zn/Co substitution ability in the polar diatom Chaetoceros RS19. In revision at Limnol. Oceanogr.

Kellogg* Riss M., Mark A. Moosburner, Natalie R. Cohen+, Nicholas J. Hawco*, Matthew R. McIlvin, Dawn M. Moran, Andrew E. Allen, Mak A. Saito. Two zinc and cobalt-responsive proteins in marine eukaryotic phytoplankton and implications for Zn scarcity in the surface oceans. Submitted.

McIlvin, M.R. and Saito, M.A., 2021. Online Nanoflow Two-Dimension Comprehensive Active Modulation Reversed Phase–Reversed Phase Liquid Chromatography High-Resolution Mass Spectrometry for Metaproteomics of Environmental and Microbiome Samples. Journal of Proteome Research.

Tanya Marshall, Julie Granger, Karen L. Casciotti, Kirstin Dähnke, Kay-Christian Emeis, Dario Marconi, Matthew R. McIlvin, Abigail E. Noble, Mak A. Saito, Daniel M. Sigman, and Sarah E. Fawcett. Sedimentary iron and excess phosphate jointly regulate N2 fixation in the South Atlantic. Submitted.

Mazzotta+ Michael G, Matthew R. McIlvin, Dawn M. Moran, David T. Wang, Kay D. Bidle, Carl H. Lamborg, Mak A. Saito. 2021. Characterization of the metalloproteome of Pseudoalteromonas (BB2-AT2): biogeochemical underpinnings for zinc, manganese, cobalt and nickel cycling in a ubiquitous marine heterotroph. In press at Metallomics.

Cohen, N.R., Noble, A.E., Moran, D.M., McIlvin, M.R., Goepfert, T.J., Hawco, N.J., German, C.R., Horner, T.J., Lamborg, C.H., McCrow, J.P. and Allen, A.E., 2021. Hydrothermal trace metal release and microbial metabolism in the Northeast Lau Basin of the south Pacific Ocean. Biogeosciences.  1-39.

Oldham, V.E., Chmiel, R., Hansel, C.M., DiTullio, G.R., Rao, D. and Saito, M., 2021. Inhibited manganese oxide formation hinders cobalt scavenging in the Ross Sea. Global Biogeochemical Cycles35(5), p.e2020GB006706.

Bianchi, T.S., Anand, M., Bauch, C.T., Canfield, D.E., De Meester, L., Fennel, K., Groffman, P.M., Pace, M.L., Saito, M. and Simpson, M.J., 2021. Ideas and perspectives: Biogeochemistry–some key foci for the future. Biogeosciences18(10). 3005-3013.

Held, N.A., Sutherland, K.M., Webb, E.A., McIlvin, M.R., Cohen, N.R., Devaux, A.J., Hutchins, D.A., Waterbury, J.B., Hansel, C.M. and Saito, M.A., 2021. Mechanisms and heterogeneity of in situ mineral processing by the marine nitrogen fixer Trichodesmium revealed by single-colony metaproteomics. ISME Communications1(1), pp.1-9.

Natalie R. Cohen+, Matthew R. McIlvin, Dawn M. Moran, Noelle A. Held*, Jaclyn K. Saunders+, Nicholas J. Hawco, Michael Brosnahan, Giacomo R. DiTullio, Carl Lamborg, John P. McCrow, Chris L. Dupont, Andrew E. Allen, Mak A. Saito. 2021. Dinoflagellates contribute to primary and secondary production in the central Pacific Ocean. Nature Microbiology.

M.A. Saito, Jaclyn K. Saunders+, Michael Chagnon, David Gaylord, Adam Shepherd, Noelle A. Held*, Chris Dupont, Nick Symmonds, Amber York, Matt Charron, Danie Kinkade. 2021 Development of an Ocean Protein Portal for Interactive Discovery and Education. J. Proteome Research.   20, 326-336.

Julia M. Gauglitz+, Rene M. Boiteau, Craig McLean, Lydia Babcock-Adams, Matthew R. McIlvin, Dawn M. Moran, Daniel J. Repeta, Mak A. Saito. 2021. Dynamic proteome response of a marine Vibrio to a gradient of iron and ferrioxamine bioavailability. Marine Chemistry. 229.


Barbara Bayer, Mak A. Saito, Matthew R. McIlvin, Sebastian Lücker, Dawn M. Moran, Thomas S. Lankiewicz, Christopher L. Dupont, and Alyson E. Santoro. 2020. Metabolic versatility of the nitrite-oxidizing bacterium Nitrospira marina and its proteomic response to oxygen-limited conditions. ISME.

Breier, John C., Michael V. Jakuba, Mak A. Saito, Gregory J. Dick, Sharon L. Grim, Eric W. Chan, Matthew R. McIlvin, Dawn M. Moran, Brianna A. Alanis, Andrew E. Allen, Chris L. Dupont, Rod Johnson. 2020. Robotic oceanography: Revealing ocean-scale biochemical structure with a deep-diving autonomous vehicle. Science Robotics.

Saunders+, Jaclyn K., David Gaylord, Noelle Held*, Nick Symmonds, Chris Dupont, Adam Shepherd, Danie Kinkade, Mak A. Saito. 2020. METATRYP v 2.0: Metaproteomic Least Common Ancestor Analysis for Taxonomic Inference Using Specialized Sequence Assemblies - Standalone Software and Web Servers for Marine Microorganisms and Coronaviruses. J. Proteome Research. 19, 4718-4729.

Mazzotta+ M, McIlvin MR, Saito MA. Characterization of the Fe Metalloproteome of a Ubiquitous Marine Heterotroph, Pseudoalteromonas (BB2-AT2): Multiple Bacterioferritin Copies Enable Significant Fe Storage. Metallomics. 12, 654-667. DOI: 10.1039/D0MT00034E

Mak A. Saito, Matthew R. McIlvin, Dawn M. Moran, Alyson E. Santoro, Chris L. Dupont, Patrick Rafter, Jaclyn Saunders+, Drishti Kaul, Carl H. Lamborg, Marian Westley, Frederica Valois, John B. Waterbury. 2020. Abundant nitrite-oxidizing metalloenzymes in the mesopelagic zone of the tropical Pacific Ocean. Nature Geosciences, 13(5). 355-362.

Nicholas J. Hawco*, Matthew M. McIlvin, Randelle M. Bundy+, Alessandro Tagliabue, Tyler J. Goepfert*, Dawn M. Moran, Luis Valentin-Alvarado, Giacomo R. DiTullio, and Mak A. Saito. 2020. Minimal cobalt metabolism in the marine cyanobacterium Prochlorococcus. Proc. Natl. Acad. Sci.  117(27). 15740-15747.

Bundy+, R. M., Tagliabue, A., Hawco, N. J., Morton, P. L., Twining, B. S., Hatta, M., Noble, A., Cape, M. R., John, S. G., Cullen, J. T., and Saito, M. A. 2020. Elevated sources of cobalt in the Arctic Ocean. Biogeosciences.

Morel, F.M., Lam, P.J. and Saito, M.A., 2020. Trace Metal Substitution in Marine Phytoplankton. Annual Review of Earth and Planetary Sciences48:491-517.

Marissa Kellogg*, Matthew R. McIlvin, Jagruti Vedamati, Benjamin S. Twining, James W. Moffett, Adrian Marchetti, Dawn M. Moran, Mak A. Saito. Efficient zinc/cobalt interreplacement in northeast Pacific diatoms and relationship to high surface dissolved Co:Zn ratios. 2020. Limnol. Oceanogr.

Held*, N.A., Webb, E.A., McIlvin, M.M., Hutchins, D.A., Cohen, N.R., Moran, D.M., Kunde, K., Lohan, M.C., Mahaffey, C.M., Woodward, E.M.S. and Saito, M.A., 2020. Co-occurrence of Fe and P stress in natural populations of the marine diazotroph TrichodesmiumBiogeosciences. 17. 2537-2551.

Matthew A Charette, Lauren E Kipp, Laramie T Jensen, Jessica S Dabrowski, Laura M Whitmore, Jessica N Fitzsimmons, Tatiana Williford, Adam Ulfsbo, Elizabeth Jones, Randelle M Bundy, Sebastian M Vivancos, Katharina Pahnke, Seth G John, Yang Xiang, Mariko Hatta, Mariia V Petrova, Lars‐Eric Heimbürger‐Boavida, Dorothea Bauch, Robert Newton, Angelica Pasqualini, Alison M Agather, Rainer MW Amon, Robert F Anderson, Per S Andersson, Ronald Benner, Katlin L Bowman, R Lawrence Edwards, Sandra Gdaniec, Loes JA Gerringa, Aridane G González, Mats Granskog, Brian Haley, Chad R Hammerschmidt, Dennis A Hansell, Paul B Henderson, David C Kadko, Karl Kaiser, Patrick Laan, Phoebe J Lam, Carl H Lamborg, Martin Levier, Xianglei Li, Andrew R Margolin, Chris Measures, Rob Middag, Frank J Millero, Willard S Moore, Ronja Paffrath, Hélène Planquette, Benjamin Rabe, Heather Reader, Robert Rember, Micha JA Rijkenberg, Matthieu Roy‐Barman, Michiel Rutgers van der Loeff, Mak Saito, Ursula Schauer, Peter Schlosser, Robert M Sherrell, Alan M Shiller, Hans Slagter, Jeroen E Sonke, Colin Stedmon, Ryan J Woosley, Ole Valk, Jan van Ooijen, Ruifeng Zhang. The Transpolar Drift as a Source of Riverine and Shelf‐Derived Trace Elements to the Central Arctic Ocean. Journal of Geophysical Research: Oceans 125, no. 5 (2020): e2019JC015920.


Keisuke Inomura, Curtis Deutsch, Samuel T. Wilson, Takako Masuda, Evelyn Lawrenz, 4 Bučinská Lenka, Roman Sobotka, Julia M. Gauglitz, Mak A. Saito, Ondřej Prášil and Michael J. Follows. 2019. Quantifying oxygen management and temperature-light dependencies of nitrogen fixation by Crocosphaera watsonii. mSphere. DOI:10.1128/mSphere.00531-19.

Julia M. Diaz, Sydney Plummer, Colleen M. Hansel, Peter F. Andeer, Mak A. Saito, and Matthew R. McIlvin. 2019. NADPH-dependent extracellular superoxide production is vital to photophysiology in the marine diatom Thalassiosira oceanica. Proceedings of the National Academy of Sciences. 116(33), 16448-16453.

Michael D Lee, Nathan A Ahlgren, Joshua D Kling, Nathan G Walworth, Gabrielle Rocap, Mak A Saito, David A Hutchins, Eric A Webb. 2019. Marine Synechococcus isolates representing globally abundant genomic lineages demonstrate a unique evolutionary path of genome reduction without a decrease in GC content. Environmental Microbiology 21 (5), 1677-1686

Noelle A Held+, MR McIlvin, DM Moran, MT Laub, MA Saito. Unique Patterns and Biogeochemical Relevance of Two-Component Sensing in Marine Bacteria. 2019. MSystems 4 (1), e00317-18

Saito, Mak; Bertrand, Erin ; Duffy, Megan; Gaylord, David; Held, Noelle; Hervey, Judson; Hettich, Robert; Jagtap, Pratik; Janech, Michael ; Kinkade, Danie; Leary, Dagmar ; McIlvin, Matthew; Moore, Eli; Morris, Robert; Neely, Benjamin; Nunn, Brook; Saunders, Jaclyn; Shepherd, Adam; Symmonds, Nick; Walsh, David. 2019. Progress and Challenges in Ocean Metaproteomics and Proposed Best Practices for Data Sharing. Journal of Proteome Research. 18 (4), 1461-1476

Gunnar F Kwakye, Jessica A Jiménez, Morgan G Thomas, Brett A Kingsley, Matthew McIIvin, Mak A Saito, Edmund M Korley. 2019 Heterozygous huntingtin promotes cadmium neurotoxicity and neurodegeneration in striatal cells via altered metal transport and protein kinase C delta dependent oxidative stress and apoptosis signaling mechanisms. Neurotoxicology 70, 48-61

Kathleen M. Munson, Carl H. Lamborg, Rene M. Boiteau, and Mak A. Saito. Dynamic mercury methylation and demethylation in oligotrophic marine waters. 2018. Biogeosciences. 15 (21), 6451-6460

Cohen+, Natalie R., Weida Gong, Dawn M. Moran, Matthew R. McIlvin, Mak A. Saito, and Adrian Marchetti. 2018. Transcriptomic and proteomic responses of the oceanic diatom Pseudo‐nitzschia granii to iron limitation. Environmental microbiology. 20 (8), 3109-3126

Emma Tarrant, Gustavo P. Riboldi, Matthew R. McIlvin, Jack Stevenson, Anna Barwinska-Sendra, Louisa J. Stewart, Mak A. Saito, Kevin J. Waldron.  2019. Proteomic analysis of the response of Staphylococcus aureus to elevated copper indicates major effects on metal homeostasis and alterations to carbon metabolism. Metallomics. 11 (1), 183-200.


MV Jakuba, JA Breier, D Gómez-Ibáñez, K Tradd, MA Saito. 2018. Clio: An Autonomous Vertical Sampling Vehicle for Global Ocean Biogeochemical Mapping. 2018. IEEE/OES Autonomous Underwater Vehicle Workshop (AUV), 1-8.

Bender+, S.J., D. Moran, M.R. McIlvin, H. Zheng, J.P. McCrow, J. Badger, G.R. DiTullio, A.E. Allen, M.A. Saito. 2018. Colony formation in Phaeocystis antarctica: connection molecular mechanisms to iron biogeochemistry. Biogeosciences 15, 4923-4942,

Held*, Noelle and Saunders, Jaclyn and Futrelle, Joe and Saito, Mak. Harnessing the Power of Scientific Python to Investigate Biogeochemistry and Metaproteomes of the Central Pacific Ocean. Proceedings of the Python in Science Conference, 2018. doi:10.25080/Majora-4af1f417-010

Schlitzer, Reiner; Anderson, Robert F; Dodas, Elena Masferrer; Lohan, Maeve; Geibert, Walter; Tagliabue, Alessandro; Bowie, Andrew; Jeandel, Catherine; Maldonado, Maria T; Landing, William M; Cockwell, Donna; Abadie, Cyril; Abouchami, Wafa; Achterberg, Eric P; Agather, Alison; Aguliar-Islas, Ana; Van Aken, Hendrik M; Andersen, Morten; Archer, Corey; Auro, Maureen; De Baar, Hein J; Baars, Oliver; Baker, Alex R; Bakker, Karel; Basak, Chandranath; Baskaran, Mark; Bates, Nicholas R; Bauch, Dorothea; Van Beek, Pieter; Behrens, Melanie K; Black, Erin; Bluhm, Katrin; Bopp, Laurent; Bouman, Heather; Bowman, Katlin; Bown, Johann; Boyd, Philip; Boye, Marie; Boyle, Edward A; Branellec, Pierre; Bridgestock, Luke; Brissebrat, Guillaume; Browning, Thomas; Bruland, Kenneth W; Brumsack, Hans-Jürgen; Brzezinski, Mark; Buck, Clifton S; Buck, Kristen N; Buesseler, Ken; Bull, Abby; Butler, Edward; Cai, Pinghe; Mor, Patricia Cámara; Cardinal, Damien; Carlson, Craig; Carrasco, Gonzalo; Casacuberta, Núria; . The GEOTRACES Intermediate Data Product 2017. Chemical Geology. 493. 210-223.

Moffett, James W; German, Christopher R; Peters, Brian D; Jenkins, William J; Swift, James H; Casciotti, Karen L; Sanial, V; Kipp, LE; Henderson, PB; van Beek, P; Charette, MA; Black, Erin E; Buesseler, Ken O; Pike, Steven M; Lam, Phoebe J; Kipp, Lauren E; Sanial, Virginie; Henderson, Paul B; van Beek, Pieter; Charette, Matthew A; John, Seth G; Helgoe, Joshua; Townsend, Emily; Weber, Tom; Till, Claire; Cutter, Gregory A; Moffett, James G; Nielsdóttir, Maria C; Lee, Jong-Mi; Heller, Maija I; Mehic, Sanjin; Bates, Nicholas R; Ohnemus, Daniel C; Twining, Benjamin S; Hawco, Nicholas J; Saito, Mak A; Lott, Dempsey E; Cahill, Kevin L; Longworth, Brett; Hoffman, Colleen L; Nicholas, Sarah L; Fitzsimmons, Jessica N; Toner, Brandy M; Marsay, Chris M; Pavia, Frank; Anderson, Robert; Vivancos, Sebastian; Fleisher, Martin; Edwards, R Lawrence; Buck, Kristen N; Sedwick, Peter N; Sohst, Bettina; Carlson, Craig A; Ho, Peng; Shiller, Alan M. 2018. The US GEOTRACES Eastern Tropical Pacific Transect (GP16). Marine Chemistry. 201. 1-5.

Bundy+, Randelle M., Rene M. Boiteau, Craig McLean, Kendra A. Turk-Kubo, Matt R. McIlvin, Mak A. Saito, Benjamin AS Van Mooy, and Daniel J. Repeta. 2018. Distinct Siderophores Contribute to Iron Cycling in the Mesopelagic at Station ALOHA. Frontiers in Marine Science 5 (2018): 61.

Tagliabue, Alessandro, Nicholas J. Hawco, Randelle M. Bundy, William M. Landing, Angela Milne, Peter L. Morton, and Mak A. Saito. 2018. The role of external inputs and internal cycling in shaping the global ocean cobalt distribution: insights from the first cobalt biogeochemical model. Global Biogeochemical Cycles 32, no. 4. 594-616.

Walworth, Nathan G., Michael D. Lee, Christopher Suffridge, Pingping Qu, Fei-Xue Fu, Mak A. Saito, Eric A. Webb, Sergio A. Sañudo-Wilhelmy, and David A. Hutchins.2018. Functional genomics and phylogenetic evidence suggest genus-wide cobalamin production by the globally distributed marine nitrogen fixer TrichodesmiumFrontiers in Microbiology 9. 189.

Hawco*, Nicholas J., and Mak A. Saito. 2018. Competitive inhibition of cobalt uptake by zinc and manganese in a Pacific Prochlorococcus strain: Insights into metal homeostasis in a streamlined oligotrophic cyanobacterium. Limnology and Oceanography. 63(5). 2229-2249.

NG Walworth, FX Fu, MD Lee, X Cai, MA Saito, EA Webb, DA Hutchins. Nutrient-colimited Trichodesmium as a nitrogen source or sink in a future ocean. 2018. Appl. Environ. Microbiol. 84 (3), e02137-17.


Lee, M.D., Webb, E.A., Walworth, N.G., Fu, F.X., Held*, N.A, Saito, M.A., Hutchins, D.A.  2017. Transcriptional profiles of the Trichodesmium consortium following long term CO2 adaptation: community nitrogen cycling, respiration, and ecological niche-space delineation. Applied and Environmental Microbiology. AEM-02026.

Hawco*, N.J., Lam, P.J., Lee, J.M., Ohnemus, D.C., Noble*, A.E., Wyatt, N.J., Lohan, M.C. and Saito, M.A., 2017. Cobalt scavenging in the mesopelagic ocean and its influence on global mass balance: Synthesizing water column and sedimentary fluxes. Marine Chemistry. 201. 151-166.

Saito, Mak A., Abigail E. Noble*, Dan Ohnemus, Nicholas Hawco*, Seth John, Phoebe Lam, Ben Twining, Rod Johnson, Dawn Moran, Matthew McIlvin. 2017. The Acceleration of Dissolved Cobalt’s Ecological Stoichiometry due to Biological Uptake, Remineralization, and Scavenging in the Atlantic Ocean. Biogeosciences. 14:20. 4637-4662.

Noble*, A. E., Ohnemus, D. C., Hawco*, N. J., Lam, P. J., & Saito, M. A. 2017. Coastal sources, sinks and strong organic complexation of dissolved cobalt within the US North Atlantic GEOTRACES transect GA03. Biogeosciences, 14(11), 2715-2739. doi: 10.5194/bg-14-2715-2017

Hutchins, D. A., Fu, F., Walworth, N. G., Lee, M. D., Saito, M. A., & Webb, E. A. 2017. Comment on “The complex effects of ocean acidification on the prominent N2-fixing cyanobacterium Trichodesmium”. Science, 357(6356), eaao0067.

Santoro, A. E., Saito, M. A., Goepfert*, T. J., Lamborg, C. H., Dupont, C. L., & DiTullio, G. R. 2017. Thaumarchaeal ecotype distributions across the equatorial Pacific Ocean and their potential roles in nitrification and sinking flux attenuation. Limnology and Oceanography. 62. 1984-2003.

Tagliabue, Alessandro, Andrew Bowie, Philip Boyd, Kristen Buck, Kenneth Johnson, Mak Saito. 2017. New insights into the modulation of ocean biogeochemistry by iron. 543. 51-59. Nature.

Chong, W., Jiménez, J., McIIvin, M., Saito, M. A., & Kwakye, G. F. 2017. α-Synuclein Enhances Cadmium Uptake and Neurotoxicity via Oxidative Stress and Caspase Activated Cell Death Mechanisms in a Dopaminergic Cell Model of Parkinson’s Disease. Neurotoxicity Research. 1-16.

Sanial, V., Kipp, L., Henderson, P., van Beek, P., Reyss, J.-L., Hammond, D., Hawco, N., Saito, M., Resing, J., and Sedwick, P. 2018. Radium-228 as a tracer of dissolved trace element inputs from the Peruvian continental margin, Marine Chemistry. 201, 20-34.


Boiteau, Rene, Claire P. Till, Angel Ruacho, Randelle M. Bundy, Nicholas J. Hawco*, Amy M. McKenna, Katherine A. Barbeau, Kenneth W. Bruland, Mak A. Saito, Daniel J. Repeta. 2016.Structural Characterization of Natural Nickel and Copper Binding Ligands along the US GEOTRACES Eastern Pacific Zonal Transect. Frontiers in Marine Science. 3.

Noble, A. E., D.C. Ohnemus, N. Hawco, P.J. Lam, and M.A. Saito. 2016. Coastal Sources, Sinks, and Strong Organic Complexation of Dissolved Cobalt within the US North Atlantic GEOTRACES Zonal Transect GA03. In review at Biogeosciences

Saito, Mak A., Abigail E. Noble*, Dan Ohnemus, Nicholas Hawco, Seth John, Phoebe Lam, Ben Twining, Rod Johnson, Dawn Moran, Matthew McIlvin. Dissolved Cobalt and Speciation from the US North Atlantic GEOTRACES Zonal Transect: The Acceleration of Dissolved Cobalt’s Ecological Stoichiometry due to Biological Uptake, Remineralization, and Scavenging in the Atlantic Ocean. In review at Biogeosciences.

Robbins, Jamie, Brian Kendall, Noah Planavsky, Chris Reinhard, Camille Partin, Stefan Lalonde, Clint Scott, Dalton Hardisty, Simon Poulton, Andrey Bekker, Tim Lyons, Mak Saito, Chris Dupont, Dan Alessi, Ross Large, Kurt Konhauser. Trace elements at the intersection of biological and marine geochemical evolution. 2016. Earth Science Reviews. 163. 323-348.

Hawco, N.J., D.C. Ohnemus, J.A. Resing, B.S. Twining, M.A. Saito. 2016. A cobalt plume in the oxygen minimum zone of the Eastern Tropical South Pacific. Biogeosciences. 2016. 1-60.

Walworth, Nathan G., Fei-Xue Fu, Eric A. Webb, Mak A. Saito, Dawn Moran, Matthew R. Mcllvin, Michael D. Lee, David A. Hutchins. 2016. Mechanisms of increased Trichodesmium fitness under iron and phosphorus co-limitation in the present and future ocean. Nature Communications. 7. 12081.

Boiteau, Rene M., Daniel R. Mende, Nicholas J. Hawco, Matthew R. McIlvin, Peter N. Sedwick, Mak A. Saito, Edward F. Delong, Daniel J. Repeta. Siderophore-based microbial adaptations to iron scarcity across the eastern Pacific Ocean. In Press at Proc. Natl. Acad. Sci.

Alyson E. Santoro, Mak A. Saito, Tyler J. Goepfert, Carl H. Lamborg, Chris L. Dupont, Giacomo R. DiTullio. Thaumarchaeal ecotype distributions across the equatorial Pacific Ocean and their potential roles in nitrification and sinking flux attenuation. In revision at Limnol. Oceanogr.

Zheng, Xin-Yuan, Yves Plancherel, Mak A. Saito, Gideon M. Henderson. 2016. Rare earth elements (REEs) in the tropical South Atlantic and quantitative deconvolution of their non-conservative behavior. Geochimica Cosmochimica Acta. 177. 217-237.

Mackey, Katherine R.M., Anton F. Post, Matthew R. McIlvin, Mak A. Saito.. A spectrum of light preferences among marine Synechococcus. Submitted


Lee, Peter A. Erin M. Bertrand*, Mak A. Saito, Giacomo R. DiTullio. 2015. Influence of Vitamin B12 availability on oceanic dimethylsulfide. Environmental Chemistry.

Swanner, Elizabeth D., Wenfang Wu, Likai Hao, Marina Wuestner, Martin Obst, Dawn Michelle Moran, Matthew McIlvin, Mak Saito, Andreas Kappler. 2015. Physiology, Fe(II) oxidation, and Fe mineral formation by a marine planktonic cyanobacterium grown under ferruginous conditions. Frontiers in Earth Science Biogeoscience.

The GEOTRACES Group. 2015. The GEOTRACES intermediate data product 2014. Marine Chemistry 177. 1-8.

Munson, K.M., C.H. Lamborg, G.J. Swarr, M.A. Saito. 2015. Mercury Species Concentrations and Fluxes in the Central Tropical Pacific Ocean. Global Biogeochemical Cycles. DOI: 10.1002/2015GB005120.

Guannel, M., D. Haring, M.Twiner, Z.Wang, A. Noble, P. Lee, M. Saito, G. Rocap. Toxigenicity and biogeography of the diatom Pseudo-nitzschia across distinct environmental regimes in the South Atlantic Ocean. 2015.Marine Ecology Progress Series, 526. 67-87.

Boyle, E.A., R.F. Anderson,  G.A. Cutter,  R. Fine, , W.J. Jenkins, , M. Saito. 2015. Introduction to the US GEOTRACES North Atlantic Transect (GA-03): USGT10 and USGT11 cruises. Deep Sea Research Part II: Topical Studies in Oceanography. 116. 1-5.

Mackey, K.M., A.F. Post, M.R. McIlvin, G.A. Cutter, S. John, M.A. Saito.  Divergent responses of Atlantic coastal and oceanic Synechococcus to iron limitation. Proceedings of the National Academy of Sciences. 112:32. 9944–9949, doi: 10.1073/pnas.1509448112

Hutchins, D.A., Nathan S. Walworth, Eric A. Webb, Mak A. Saito, Dawn Moran, Matthew R. McIlvin, Jasmine Gale, and Fei-Xue Fu. 2015. Irreversibly increased nitrogen fixation in Trichodesmium experimentally adapted to elevated carbon dioxide. Nature. doi:10.1038/ncomms9155

Saito, M. A.; Dorsk, A.; Post, A. F.; McIlvin, M.; Rappé, M. S.; DiTullio, G.; Moran, D. 2015. Needles in the Blue Sea: Sub‐Species Specificity in Targeted Protein Biomarker Analyses Within the Vast Oceanic Microbial Metaproteome. Proteomics. DOI: 10.1002/pmic.201400630

Jill Sohm, Nathan Ahlgren, Zachary Thomson, Cheryl Williams, James Moffett, Mak Saito, and Eric Webb, Gabrielle Rocap. 2015. Co-occurring Synechococcus ecotypes occupy four major oceanic regimes defined by temperature, macronutrients, and iron. ISME Journal. doi: 10.1038/ismej.2015.115

Alyson E Santoro, Christopher L Dupont, R Alex Richter, Matthew T Craig, Paul Carini, Matthew R McIlvin, Youngik Yang, William D Orsi, Dawn M Moran, Mak A Saito. 2015. Genomic and proteomic characterization of “Candidatus Nitrosopelagicus brevis”: An ammonia-oxidizing archaeon from the open ocean. Proceedings of the National Academy of Sciences. 201416223.

Tristan J Horner, Helen M Williams, James R Hein, Mak A Saito, Kevin W Burton, Alex N Halliday, Sune G Nielsen. Persistence of deeply sourced iron in the Pacific Ocean. Proceedings of the National Academy of Sciences. 201420188.

Katherine RM Mackey, Chia-Te Chien, Anton F Post, Mak A Saito, Adina Paytan. 2015. Rapid and gradual modes of aerosol trace metal dissolution in seawater. Frontiers in Microbiology. 5, 794.


Lamborg, C.H., C.R. Hammerschmidt, K.L. Bowman, G.J. Swarr, K.M. Munson, D.C. Ohnemus, P.J. Lam, L.-E. Heimburger, M.J.A. Rijkenberg, and M.A. Saito. 2014. A global ocean inventory of anthropogenic mercury based on water column measurements. Nature. 512. 65-68.

Austin, Rachel Narehood, Mak A. Saito. 2014. Metals in Marine Biochemistry. Metallomics. 6.6. 1105-1106.

Mak A. Saito, Matthew R. McIlvin, Dawn M. Moran, Tyler J. Goepfert, Giacomo R. DiTullio, Anton F. Post, Carl H. Lamborg. 2014. Multiple nutrient stresses at intersecting Pacific Ocean biomes detected by protein biomarkers. Science, Vol. 345 No. 6201, pp. 1173-1177. DOI: 10.1126/science.1256450. [Abstract | Reprint | Full Text]

AD Cox, AE Noble, MA Saito. 2014. Cadmium enriched stable isotope uptake and addition experiments with natural phytoplankton assemblages in the Costa Rica Upwelling Dome. Marine Chemistry 166, 70-81.

Elizabeth D Swanner, Noah J Planavsky, Stefan V Lalonde, Leslie J Robbins, Andrey Bekker, Olivier J Rouxel, Mak A Saito, Andreas Kappler, Stephen J Mojzsis, Kurt O Konhauser. Cobalt and marine redox evolution.  2014. Earth and Planetary Science Letters 390, 253-263.

Nathan A. Ahlgren, Abigail Noble, Alison Patton, Kathryn Roache-Johnson, Laurel Jackson, Daniela Robinson, Lisa Moore, Mak Saito, Gabrielle Rocap. The unique trace metal and macronutrient conditions of the Costa Rica upwelling dome support a distinct and dense community of Synechococcus. 2014. Limnology and Oceanography. 59 (6), 2166-2184.


Moore, C.M., Mills, M.M., Arrigo, K.R., Berman-Frank, I., Bopp, L., Boyd,P.W., Galbraith, E.D., Geider, R.J., Guieu, C., Jaccard, S.L., Jickells, T.D., LaRoche, J., Lenton, T., Mahowald, N.M., Marañón, E., Marinov, I., Moore,J.K., Nakatsuka, T., Oschlies, A., Saito, M.A., Thingstad, T.F., Tsuda, A.,Ulloa, O. and Wallace, D. 2013. Oceanic nutrient limitation: processes, patterns and potential for change. Nature Geosciences.

Alysia Cox* and Mak Saito. 2013. Proteomic responses of oceanic Synechococcus WH8102 to phosphate and zinc scarcity and cadmium additions. Frontiers in Microbiological Chemistry. 4:387. doi: 10.3389/fmicb.2013.00387

Abigail E. Noble*, Dawn M. Moran, Andrew E. Allen, and Mak A. Saito. 2013. Dissolved and particulate trace metal micronutrients under the McMurdo Sound seasonal sea ice: basal sea ice communities as a capacitor for iron. Frontiers in Microbiological Chemistry. doi: 10.3389/fchem.2013.00025

Mackey, KRM, K Caldiera, A Grossman, D Moran, M McIlvin, A Paytan, & M Saito. 2013. Effect of temperature on photosynthesis and growth in diverse marine Synechococcus strains. Plant Physiology. DOI:10.1104/pp.113.221937

Saito, M.A., A.E. Noble, T. J. Goepfert, C.H. Lamborg, W.J. Jenkins. 2013. Slow-spreading submarine ridges in the South Atlantic as a significant oceanic iron source. 2013 | DOI: 10.1038/NGEO1893.  Nature Geosciences.

Erin M. Bertrand, Dawn M. Moran, Matthew R. McIlvin, Jeffrey M. Hoffman, Andrew E. Allen, and Mak A. Saito. 2013. Methionine synthase interreplacement in diatom cultures and communities.  Limnology and Oceanography.

J. Daphne Aguirre, Hillary M. Clark, Matthew McIlvin, Christine Vazquez, Shaina L. Palmere, Dennis Grab, J. Seshu, Mak Saito, and Valeria C. Culotta. 2013. A Manganese-Rich Environment Supports Superoxide Dismutase Activity in the Lyme Disease Pathogen, Borrelia burgdorferi. Journal of Biological Chemistry.

L. J . ROBBINS, S. V. LALONDE, M. A. SAITO, N. J . PLANAVSKY, A. M. MLOSZEWSKA, E. PECOITS, C. SCOTT, C. L. DUPONT, A. KAPPLER7 AND K. O. KONHAUSER. 2013. Authigenic iron oxide proxies for marine zinc over geological time and implications for eukaryotic metallome evolution. Geobiology. DOI: 10.1111/gbi.12036.


Bertrand EM*, Allen AE, Dupont CL, Norden-Krichmar T, Bai J, Saito MA. 2012. Impact of Cobalamin Starvation on Diatom Molecular Physiology and the Identification of a Novel Cobalamin Acquisition Protein. Proc. Natl. Acad. Sci.

Noble, A.E., C.H. Lamborg,  D. Ohnemus,  P.J. Lam, K. T.J. Goepfert, C.I. Measures, C.H. Frame, K.L. Casciotti, G.R.DiTullio, J. Jennings, and M.A. Saito. 2012. Basin-scale plumes of cobalt, iron, and manganese emanating from the Benguela-Angola front in the South Atlantic Ocean. Limnology and  Oceanography.

Alexander H, Jenkins BD, Rynearson TA, Saito MA, Mercier ML and Dyhrman ST (2012) Identifying reference genes with stable expression from high throughput sequence data. Frontiers in Aquatic Microbiology. 3:385. doi: 10.3389/fmicb.2012.00385

Katherine RM Mackey, Kathryn Roberts, Michael W Lomas, Mak A Saito, Anton F Post, Adina Paytan. 2012. Variable solubility and ecological impact of atmospheric phosphorus deposition. Environ. Sci. Technol.

Mak A. Saito. 2012. The Rise of Oxygen and Aerobic Biochemistry. Structure. 20:1. 1–2.

Gregory F. de Souza, Ben C. Reynolds, Jörg Rickli, Martin Frank, Mak Saito, Loes J. A. Gerringa and Bernard Bourdon. 2012. Southern Ocean control of silicon stable isotope distribution in the deep Atlantic Ocean. Global Biogeochemical Cycles.

Sonya T. Dyhrman, Bethany D. Jenkins, Tatiana A. Rynearson, Mak A. Saito, Melissa L. Mercier, Harriet Alexander, LeAnn P. Whitney, Andrea Drzewianowski, Vladimir V. Bulygin, Erin M. Bertrand, Zhijin Wu, Claudia Benitez-Nelson, Abigail Heithoff. 2012 Coordination in the transcriptome and proteome of the diatom Thalassiosira pseudonana reveals a diverse phosphorus stress response. PLoS One.

Jakuba, R., M.A. Saito, J.W. Moffett , Y. Xu. 2012. Dissolved zinc in the subarctic North Pacific and Bering Sea: Its distribution, speciation, and importance to primary producers. Global Biogeochemical Cycles.


Mak Saito, Vladimir Bulygin, Dawn Moran, Craig Taylor, and Christopher Scholin. 2011. Examination of Microbial Proteome Preservation Techniques Applicable to Autonomous Environmental Sample Collection. Frontiers in Aquatic Microbiology.

Saito, M.A., E.M. Bertrand, V. Bulygin, D. Moran, S. Dutkiewicz, F.M. Monteiro, M.J. Follows, F.W. Valois, J.B. Waterbury.  2011. Iron Conservation by Reduction of Metalloenzyme Inventories in the Marine Diazotroph Crocosphaera watsoniiProc. Natl. Acad. Sci. doi:10.1073/pnas.1006943108. Supplemental Materials and Dataset.

Louie L. Wurch, Erin M. Bertrand, Mak A. Saito, Benjamin A.S. Van Mooy and Sonya T. Dyhrman. 2011. Proteome changes driven by phosphorus stress and recovery in the brown tide-forming alga, Aureococcus anophagefferens. PLoS One.

E. M. Bertrand*, M.A. Saito, P.A. Lee, R.B. Dunbar,G.R. DiTullio. 2011. Iron limitation of springtime bacterial and phytoplankton community in the Ross Sea: implications for vitamin B12 nutrition.  Frontiers in Aquatic Microbiology.

Thompson, A.W. *, K. Huang, M.A. Saito, S.W. Chisholm. 2011. Transcriptome response of high and low-light adapted Prochlorococcus strains to changing iron availability. ISME Journal.  1-15.

Erin M. Bertrand, Mak A. Saito, Young Jae Jeon and Brett A. Neilan. 2011., Vitamin B12 biosynthesis gene diversity in the Ross Sea: the identification of a new group of putative polar B12 biosynthesizersemi, Environmental Microbiology, doi:10.1111/j.1462-2920.2011.02428.x

Jill A. Sohm, Jason Hilton, Abigail Noble, Jonathan P. Zehr, Mak A. Saito, Eric A. Webb. 2011. Nitrogen fixation in the South Atlantic Gyre and the Benguela upwelling system. Geophysical Research Letters.

Gobler, C.J. et al (and 29 others). 2011. Niche of harmful alga, Aureococcus Anophagefferens, revealed through ecogenomics. In Press at Proc. Natl. Acad. Sci. 108.11: 4352-4357..

Higgins, M.B., F.L. Wolfe-Simon, R.S. Robinson, Y. Qin, M.A. Saito and A. Pearson. 2011. Paleoenvironmental implications of taxonomic variation among δ15N values of chloropigments. 75:22. 7351-7363. Geochimica et Cosmochimica Acta.

Sedwick, P. N., C. M. Marsay, A. M. Aguilar-Islas, M. C. Lohan, B. M. Sohst, M. C.Long, K. R. Arrigo, R. B. Dunbar, M. A. Saito, W. O. Smith and G. R. DiTullio. 2011. Early-season depletion of dissolved iron in the Ross Sea polynya: Implications for iron dynamics on the Antarctic continental shelf. Journal of Geophysical Research. 116:C12019.


Saito, M.A., T.J. Goepfert, A.E. Noble, P.N. Sedwick, G.R. DiTullio.  2010. A Seasonal Study of Dissolved Cobalt in the Ross Sea of Antarctica: Micronutrient Control, Absence of Observed Scavenging, and Relationships with Zn, Cd, and P. Biogeosciences.7. 4059-4082.

Wu, Z., B.D. Jenkins, T.A. Rynearson, S.T. Dyhrman, M.A. Saito, M. Mercier, L. Whitney. 2010. Empirical Bayes Analysis of Sequencing-based Transcriptional Profiling without Replicates. BMC Bioinformatics. 11:564. doi:10.1186/1471-2105-11-564.


Less Nickel for more Oxygen - Nature News and Views 2009

M.A. Saito, Nature, Vol. 458, 9 April 2009.
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Cobalt, manganese, and iron near the Hawaiian Islands: A potential concentrating mechanism for cobalt within a cyclonic eddy and implications for hybrid-type trace metals

A.E. Noble, M.A. Saito, K. Maiti, C. Benitez-Nelson, Deep Sea Research II, 2008.
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Zinc-cobalt colimitation in Phaeocystis antarctica

Saito, M.A. and T.J. Goepfert., Limnology and Oceanography, 53(1), 2008.
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Some thoughts on the concept of co-limitation: Three definitions and the importance of bioavailability

Saito, M.A., T.J. Goepfert, and J.T. Ritt, Limnology and Oceanography, 53(1), 2008, 276–290.
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Regional distributions of nitrogen-fixing bacteria in the Pacific Ocean

Church, Matthew J., Karin M. Björkman, David M. Karl, Mak A. Saito, and Jonathan P. Zehr, Limnology and Oceanography, 53(1), 2008, 63–77.
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Zinc isotope fractionation during high-affinity and low-affinity zinc transport by the marine diatom Thalassiosira oceanica

John, Seth G., Robert W. Geis, Mak A. Saito, and Edward A. Boyle, Limnology and Oceanography, 52(6), 2007, 2710–2714.
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Vitamin B12 and iron co-limitation of phytoplankton growth in the Ross Sea

E.M. Bertrand*, M.A. Saito*, J.M. Rose, C.R. Riesselman, M.C. Lohan, A.E. Noble, P.A. Lee, G.R. DiTullio (* co-authors), Limnology and Oceanography, 52(3), 2007, 1079–1093.
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Survival and growth of two heterotrophic hydrothermal vent archaea, Pyrococcus strain GB-D and Thermococcus fumicolans, under low pH and high sulfide concentrations in combination with high temperature and pressure regimes

Edgcomb, V.P., Molyneaux, S.J., Böer, S., Wirsen, C.O., Saito, M., Atkins, M.S., Lloyd, K., Teske, A., Extremophiles, 2007, 11:329–342.
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Examination of precipitation chemistry and improvements in precision using the Mg(OH)2 preconcentration ICP-MS method for high-throughput analysis of open-ocean Fe and Mn in seawater

Mak A. Saito and David L. Schneider, Analytica Chimica Acta, 565, 2006, 222–233.
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Iron Storage and DNA-Binding Dps Protein from Trichodesmium erythraeum

M. Castruita, M. Saito, P. C. Schottel, L. A. Elmegreen, S. Myneni, E. I. Stiefel and F. M. M. Morel,  Applied and Environmental Microbiology, April 2006, p. 2918–2924.
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A Cadmium Enzyme from a Marine Diatom

Todd Lane*, Mak Saito*, Graham George, Ingrid Pickering, Roger Prince, Francois Morel* (co-first authors), Nature, May 5, 2005.
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Production of cobalt binding ligands in a Synechococcus feature at the Costa Rica upwelling dome

Mak A. Saito, Gabrielle Rocap, James W. Moffett, Limnology and Oceanography, 50(1), 2005, 279–290.
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Cobalt and nickel in the Peru upwelling region: A major flux of labile cobalt utilized as a micronutrient

Mak A. Saito, James W. Moffett, Giacomo R. DiTullio, Global Biogeochemical Cycles, Vol. 18, 2004.
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Sulfide Ameliorates Metal Toxicity for Deep-Sea Hydrothermal Vent Archaea

V.P. Edgcomb, S.J. Molyneaux, M.A. Saito, K. Lloyd, S. Böer, C.O. Wirsen, M.S. Atkins and A. Teske, Applied and Environmental Microbiology, April 2004, p. 2551–2555.
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Analysis of whole genome sequence of the centric diatom Thalassiosira pseudonana

E.V. Armbrust, J.A. Berges, C. Bowler, B.R. Green, D. Martinez, N.H. Putnam, S. Zhou, A.E. Allen, K.E. Apt, M. Bechner, M.A. Brzezinski, B.K. Chaal, A. Chiovitti, A.K. Davis, M.S. Demarest, J.C. Detter, T. Glavina, D. Goodstein, M.Z. Hadi, U. Hellsten, M. Hildebrand, B.D. Jenkins, J. Jurka, V.V. Kapitonov, N. Kröger, W.W.Y. Lau, T.W. Lane, F.W. Larimer, J.C. Lippmeier, S. Lucas, M. Medina, A. Montsant, M. Obornik, M.S. Parker, B. Palenik, G.J. Pazour, P. M. Richardson, T.A. Rynearson, M.A. Saito, D.C. Schwartz, K.Thamatrakoln, K. Valentin, A.Vardi, F.P. Wilkerson, D. S. Rokhsar, Science, Vol. 306, 1 October 2004.
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The bioinorganic chemistry of the ancient ocean: the co-evolution of cyanobacterial metal requirements and biogeochemical cycles at the Archean-Proterozoic boundary?

Mak A. Saito, Daniel, M. Sigman, Francois M.M. Morel, Inorganica Chimica Acta, 356, 2003, 308-318.
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Marine Bioinorganic Chemistry: The Role of Trace of Metals in the Oceanic Cycles of Major Nutrients

Morel, F.M.M., A.J. Milligan. M.A. SaitoTreatise on Geochemistry, 2003.
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Temporal and Spatial Variability of Cobalt in the Atlantic Ocean

Mak A. Saito and J.W. Moffett, Geochimica et Cosmochimica Acta, Vol. 66, No. 11, pp. 1943–1953, 2002.
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Cobalt uptake in Prochlorococcus

M.A. Saito, J.W. Moffett, S.W. Chisholm, J.B. Waterbury, Limnology and Oceanography, 47(6), 2002, 1629–1636.
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Tolerance of flagellated protozoa to extreme environmental conditions potentially encountered at deep-sea hydrothermal vents

Atkins, M.S.; M.A. Hanna, E.A. Kupetsky, M.A. Saito, C.D. Taylor, C.O., Marine Ecology Progress Series, Vol. 226: 63–75, 2002.
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Complexation of cobalt by natural organic ligands in the Sargasso Sea as determined by a new high-sensitivity electrochemical cobalt speciation method suitable for open ocean work

Mak A. Saito and J.W. Moffett, Marine Chemistry, 75, 2001, 49–68.
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