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Some Current Collaborators


David Lamb

Professor of Biomedical Sciences, Swansea University Medical School, Swansea, Wales Guest Investigator, WHOI

David's current major interests are in the genetic and biochemical characterisation of P450 hemoprotein enzyme systems. He has worked on the structure, function and regulation of P450 enzymes for over 25 years. He is an expert in P450 protein expression in E. coli, P450 spectral and activity assays, P450 and protein crystallography and the use of mass spectrometry in orphan P450 metabolomics and proteomics. Key research highlights include: crystallization and atomic resolution of 10 streptomycete P450 enzymes (producers of medical antibiotics); structural analysis of the first active eukaryotic NADPH cytochrome P450 reductase; characterization and crystallization of the first bifunctional cytochrome P450; elucidation of the endogenous roles of many P450s involved in antibiotic biosynthetic pathways; discovery and elucidation of viral P450s.

Jennifer Schlezinger

Associate Professor of Environmental Health, Boston University School of Public Health
Guest Investigator, WHOI

In the Schlezinger laboratory, we seek to understand how exposure to environmental contaminants contributes to two pathological conditions, obesity and osteoporosis. The prevalence of each of these conditions is on the rise, and they are each significant health risks. Obesity and osteoporosis may seem like two unrelated conditions, but they are connected by shared biological pathways, pathways that can be exploited by environmental chemicals.

Metabolic disruptors are chemicals that act to control fat tissue development either by acting on the fat cells themselves or by altering food intake and metabolism by acting on the brain, pancreas, liver, gastrointestinal tract and muscle. We study four classes of metabolic disruptors, organotins (food crop fungicides, stabilizers used in plastics), phthalates (agents used to make plastics soft), polycyclic musks (fragrances) and organophosphate flame retardants (chemicals added to furniture foam and nail polish).  We use three types of models to study the hypothesis that early life exposures to environmental pollutants can deregulate bone and fat tissue homeostasis over a life time:  mammalian cell culture, an in vivo mouse model, and an in vivo zebrafish model. We collaborate with the Hahn and Stegeman laboratories at WHOI, using zebrafish to investigate chemical mechanisms of action in a whole animal model.

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