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Woods Hole Toxicology Roundtable Discussions

2017 Tox Roundtable Discussions

All presentations will be Fridays, 12-1 in Redfield 2-04 unless noted.

7/12Collen Hansel (WHOI, Marine Chemistry) "Superoxide as it relates to microbial physiology"
7/21David Lamb (Swansea Medical School) "Giant viruses and viral cytochromes P450: an enigma wrapped in a mystery" (VENUE at MBL Bay Paul Center, 12:30pm)
7/28Kirsten Sadler (NYU and MBL) "Arsenic and ethanol: a potent cocktail that elicits fatty liver disease in zebrafish"
8/4Keith Cheng (Penn State) [provisional] "Functional genomics in zebrafish"
8/11Jennifer Schlezinger (Boston University) " Bone, an underappreciated target of environmental toxicants"
8/18Leon Peshkin (Harvard Medical School) "On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development"
8/25Emmy Gordon (Rutgers University) "Sulfur mustards and ocular effects - recent findings"

2016 Toxicology Roundtable Presentations

Summer 2016

All presentations will be Fridays, 12-1 in Redfield 2-04 unless noted.

6/9Thiago Parente (Universidade Federal do Rio de Janeiro) "Diversity of Cytochrome P450 1 (CYP1) genes in Amazonian fishes"
6/17Donald Stedman (Pfizer) "What is Pfizer doing with zebrafish: Developmental Screening and more"
6/24no meeting
7/1Kim Boekelheide (Brown Univ). "Imaging 3D Human Microtissues to Modernize Toxicity Testing" To be followed by ice cream!
7/8 no meeting
7/15Arielle Woznica (UC Berkeley) "Bacterial clues, multicellularity, and mating: insights from a choanoflagellate"
7/22Martin Ronis (LSU Medical School) “Dietary N-acetylcysteine and soy protein isolate inhibit progression of fatty liver disease in rodents”
7/29NOAA Hollings Scholars - Ryan Walsh "Deiodinase 2 expression in killifish: Are there possible PCB effects in fish from New Bedford Harbor?" and Daniel Chapman "Phenotypic effects of saxitoxin in zebrafish"
8/5Jed Goldstone (WHOI) "Molluscan Cytochrome P450s" and "Risk communication on PFOS contamination of drinking water wells in Falmouth"
8/12no meeting
8/19Michael Gallo (University of Medicine and Dentistry of New Jersey) "Genetically Engineered Crops: The NAS Committee findings on risks and benefits"
9/2David Lamb (Swansea Medical School Wales) "Interesting things about novel cytochrome P450s"

2015 Presentations

Summer 2015
2015 Presentations
All presentations will be Fridays, 12-1 in Redfield 2-04 unless noted.

6/12Matt Salanga (WHOI) CRISPR-Cas9 and gene editing; recent advances and method issues
6/19Jed Goldstone and Neel Aluru (WHOI) Science presented at the 18th Pollutant Responses in Marine Organisms meeting (PRIMO18; in Trondheim May 2015)
6/26John Stegeman (WHOI) Cytochrome P450 20A1 biology and behavioral phenotypes
7/3no seminar
7/10Liz Kujawinski (WHOI) Environmental metabolomics
7/17Judy Luborksy (WHOI) The Inflammasome
7/24David Furlow (UC Davis) Thyroid hormone work (HTS), involving the EPA Tox21 group, tadpoles, zebrafish and mouse
7/31Jennifer Schlezinger (BU) Environmental PPARg Agonists: What are they doing to our metabolic and bone health?
8/7no seminar
8/14Joanna Wilson (McMaster University) Parental effects of Pharmaceuticals on Zebrafish, emphasizing Carbamazepine and Gemfibrozil
8/21Michale Gallo (Rutgers University/Robert Wood Johnson Medical) When good chemicals go bad: A history of toxicology
8/28Erica Holland (UC Davis) History and toxicology of ryanodine receptors (ER calcium channels aka the “foot protein"); a mechanism of ortho-PCB toxicity

followed by Annual Roundtable BBQ
9/11Rebecca Helm (WHOI) Tick tock tick tock: Clock mechanisms in Cnidaria
9/23Phillipe Urban (CNRS) Substrate access channels in cytochrome P450 enzymes

2014 Discussions

All presentations will be Fridays, 12-1 in Redfield 2-04 unless noted.




Emma Heart (MBL). “Mechanisms of metabolic regulation of insulin  secretion:  function and dysfunction.”



Eduardo Rosa-Molinar (MBL and U. of Puerto Rico) “Imaging and   Identifying Elements of a Fish Spinal Neural Circuit Controlling an Innate  Behavior"



Joanna Wilson (McMaster University) "Multiple stressors in fish toxicology"



Chris Reddy (WHOI) "Refining current views on the fate of oil in the ocean: Lessons learned from the Deepwater Horizon"



John Farrington (WHOI)  "The Need for Updated Human Health Risk Assessment for Oil Spill Contaminated Bivalve Seafood: Lessons from the BP-DWH Oil Spill"



Jed Goldstone (WHOI) "Screening therapies to counteract chlorpyrifos intoxication"



Nikki Traylor-Knowles (Stanford University)  "Some (do not) Like It Hot: The Role of Tumor Necrosis Factor Receptor In Heat Stressed Corals"



Judy Luborsky (Rush Medical and WHOI)  "Ovarian Ovarian cancer in humans and chickens; utility of a non-mammalian model"
(Followed by BBQ)



Emmy Gordon (Rutgers University and MBL) "Toxicology of the eye: Changes in provisional matrix after ocular mustard injury"

2013 Presentations




Kat Crawford (BU) "The public health perspective on remediation of PCB contamination in Boston Harbor"



Ann Tarrant (WHOI) "Nuclear receptors in early-diverging animal lineages"



(no meeting)



Thanos Tzounopolous (Univ. Pittsburg) "Zinc and synaptic signaling: What is the role of zinc in the nervous system?"



Laura Vandenberg and Alex Suvorov (UMass Amherst) "BPA as a model endocrine disruptor: lessons learned in the past 6 years" and TBA



David Griffith (WHOI) "Are fish and whales the main source of steroidal estrogens to a sewage-impacted coastal ocean - Massachusetts Bay?"



Josh Grey (US Coast Guard Academy and MBL) "Reductive stress and coping mechanisms in the pancreatic beta cell: roles of NQO1 and plasma membrane electron transport (PMET)"



Jeff Laskin (Rutgers) "Approaches to treating exposures to highly toxic chemicals"



Emmy Gordon (Rutgers) "Alterations in extracellular matrix and matrix metalloproteinases after vesicant injury of the cornea"



Conor O'Meara (Kalamazoo College&WHOI) "Studies of pregnane X receptor agonists and target genes in zebrafish"
Elaine Kuo (Stanford&WHOI) "Zebrafish DNA methyltransferases and their developmental regulation and induction by TCDD"



Ben Lemaire? (WHOI) "Towards the deorphanization of cytochrome P450 20A1 (CYP20A1)"

2011 Round table talks

All presentations were Fridays, 12-1 in Redfield 2-04 unless noted.

 Date  Presenter/topic
6/30 Richard DiGuilio, Duke University
"Mechanisms of PAH Developmental Toxicity and Evolved Resistance: The Elizabeth River Killifish Story"
NOTE: This is the WHOI Biology Seminar Series at 12 noon (sharp) in Redfield Auditorium

7/15  Joshua Grey, USCG Academy
"Quinone-stimulated insulin secretion – hydrogen peroxide as a second messenger"
7/22  Martin Ronis, University of Arkansas for Medical Science
"Wnt b Catenin Signalling is a Common Skeletal Target for both Alcohol and Diet"


Date Presenter/topic
 John Farrington
"Oil Pollution in the Marine Environment – An Overview and Lessons Learned from a Research Cruise to the1979 Ixtoc-I Oil Well Blowout, Bay of Campeche,Mexican Waters of the Gulf of Mexico."
NOTE: This is the WHOI Biology Seminar Series at 12 noon (sharp) in Redfield Auditorium
 Emma Heart
"The role of NQO1 in beta cell plasma membrane electron transport and insulin secretion" and discussion on alkylphenols in endocrine disruption
 Phil Gschwend, MIT
"Organic Contaminants in Sediments: (PAHs,Petroleum Hydrocarbons, PCBs, DDTs...): Getting the 'Bioavailable Dose' right!"


 Date  Presenter/topic
10 July

 Kimberly Jackson (Spelman College)

"Licorice Constituent and Androgen Receptor Modulation in Prostate Cancer Therapy"
17 July Shanta Messerli (Resident Scientist in the MBL Cellular Dynamics Program)

Patrizia Pellegatti (Visiting Researcher from Italy in the Cellular Dynamics Program)

"Sensors of extracellular ATP and applications in cancer detection" (Candle House 1st Floor)
24 July
 Joan Ruderman (Cell Biology, Harvard Medical School)

"Zebrafish embryos:  versatile sensors for hormonally active pollutants"
31 July

 Diane Heck (NYMC)

"Catalase function"
  7 Aug
 No seminar - MBL Corporation meeting
14 Aug
   John Stegeman, Sibel Karchner (WHOI), and Jeff Laskin (Rutgers)

"Aldo-keto reductase (AKR) evolution and function"
21 Aug
  Kim Boekelheide (Brown)

"Endocrine Disruptors and Male Reproductive Health"

To be held at 11AM in REDFIELD, followed by a cookout.


 Date  Presenter/topic
8 July Tom Hutchinson (Plymouth Marine Laboratory)

Pharmaceuticals and the environment: the human - wildlife connection
15 July
 David Albertini (Kansas University Medical Center)
22 July
 Mike Gallo (Rutgers)
29 July
 cancelled - Harlyn Halvorsen memorial service
5 Aug
 Jed Goldstone (WHOI)

Evolution of cytochromes P450 in metazoa
12 Aug


7 Aug
14 Aug
21 Aug  Hans Lauffer
28 Aug  John Stegeman