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Lab Publications: 1987-present

All Publications



Moldable plastics (polycaprolactone) can be acutely toxic to developing zebrafish and activate nuclear receptors in mammalian cells. 
James BD, Medvedev AV, Makarov SS, Nelson RK, Reddy CM, Hahn ME (2024)
ChemRxiv.  (submitted to ACS Biomaterial Science & Engineering)

Independently evolved pollution resistance in four killifish populations is largely explained by few variants of large effect.
Miller JT, Clark BW, Reid NM, Karchner SI, Roach JL, Hahn ME, Nacci D, Whitehead A (2024)
Evolutionary Applications 17: e13648.

Environmental and Population influences on Mummichog (Fundulus heteroclitus) Gut Microbiomes.
Ma L, Hahn ME, Karchner SI, Nacci D, Clark BW, Apprill A (2024)
bioRxiv: 2024.2001.2026.577513.

Untangling the chemical complexity of plastics to improve life cycle outcomes.
Law KL, Sobkowicz MJ, Shaver MP, Hahn ME (2024)
Nature Reviews Materials (accepted)

Implications of Exposure Route for the Bioaccumulation Potential of Nanopolystyrene Particles.
Pitt JA, Hahn ME, Aluru N (2024)
Chemosphere  351: 141133 2024

Minimizing the environmental impacts of plastic pollution through eco-design of products with low environmental persistence.
James BD, Ward CP, Hahn ME, Thorpe SJ, Reddy CM (2024)
ACS Sustainable Chemistry & Engineering.

Microplastics in Marine Food Webs.
Pitt JA, Aluru N, Hahn ME (2024)
In: Shumway SE, Ward E, editors. Plastics in the Sea: Occurrence and Impacts. (Pitt_Aluru_Hahn_FoodWebs_2024b)


Formulation controls the potential neuromuscular toxicity of polyethylene photoproducts in developing zebrafish.
James BD, Karchner SI, Walsh AN, Aluru N, Franks DG, Sullivan KR, Reddy CM, Ward CP, Hahn ME (2023)
Environmental Science and Technology 57, 7966−7977.

The Minderoo-Monaco Commission on Plastics and Human Health.
Landrigan PJ, Raps H, Cropper M, Bald C, Brunner M, Canonizado EM, Charles D, Chiles TC, Donohue MJ, Enck J, Fenichel P, Fleming LE, Ferrier-Pages C, Fordham R, Gozt A, Griffin C, Hahn ME, Haryanto B, Hixson R, Ianelli H, James BD, Kumar P, Laborde A, Law KL, Martin K, Mu J, Mulders Y, Mustapha A, Niu J, Pahl S, Park Y, Pedrotti M-L, Pitt JA, Ruchirawat M, Seewoo BJ, Spring M, Stegeman JJ, Suk W, Symeonides C, Takada H, Thompson RC, Vicini A, Wang Z, Whitman E, Wirth D, Wolff M, Yousuf AK, Dunlop S. (2023)  Annals of Global Health 89: 23, 1–215.

Developmental exposure to domoic acid targets reticulospinal neurons and leads to aberrant myelination in the spinal cord.
Panlilio JM, Hammar KM, Aluru N, Hahn ME (2023)
Scientific Reports 13: 2587



Developmental exposure to domoic acid targets reticulospinal neurons and leads to aberrant myelination in the spinal cord.
Panlilio JM, Hammar KM, Aluru N, Hahn ME (2023)
Scientific Reports 13: 25872022

Identification of environmental factors that promote intestinal inflammation.
Sanmarco LM, Chao C-C, Wang Y-C, Kenison JE, Li Z, Rone JM, Rejano-Gordillo CM, Polonio CM, Gutierrez-Vazquez C, Piester G, Plasencia A, Li L, Giovannoni F, Lee H-G, Faust Akl C, Wheeler MA, Mascanfroni I, Jaronen M, Alsuwailm M, Hewson P, Yeste A, Andersen BM, Franks DG, Huang C-J, Ekwudo M, Tjon EC, Rothhammer V, Takenaka M, de Lima KA, Linnerbauer M, Guo L, Covacu R, Queva H, Fonseca-Castro PH, Bladi MA, Cox LM, Hodgetts KJ, Hahn ME, Mildner A, Korzenik J, Hauser R, Snapper SB, Quintana FJ (2022)
Nature 611: 801–809.

Announcing the Minderoo – Monaco Commission on Plastics and Human Health.
Landrigan PJ, Raps H, Symeonides C, Chiles T, Cropper M, Enck J, Hahn ME, Kumar P, Mustapha A, Park Y, Spring M, Stegeman J, Thompson R, Wang Z, Wolff M, Yousuf A, Dunlop S (2022)
Annals of Global Health 88(1): 73, 1–9.

Formulation controls the potential toxicity of leachates from photoweathered polyethylene bags in developing zebrafish.
James BD, Karchner SI, Walsh AN, Aluru N, Franks DG, Sullivan KR, Reddy CM, Ward CP, Hahn ME (2022)

The M/V X-Press Pearl Ship Fire Produced Pyroplastics Highly Enriched in PAHs.
James BD, Reddy CM, Hahn ME, Nelson RK, de Vos A, Aluwihare L, Wade TL, Knap AH, Bera G (2022)
Environmental Science and Technology: submitted 8July2022.

Divergent Forms of Pyroplastic: Lessons Learned from the M/V X-Press Pearl Ship Fire.
James BD, Vos Ad, Aluwihare L, Youngs S, Ward CP, Nelson RK, Michel APM, Hahn ME, Reddy CM (2022)
ACS Environmental Au 2, 5, 467–479

Nematostella vectensis exhibits an enhanced molecular stress response upon co-exposure to highly weathered oil and surface UV radiation.
Berger CA, Ward CP, Karchner SI, Nelson RK, Reddy CM, Hahn ME, Tarrant AM (2022)
Marine Environmental Research 175: 105569.

Biomaterials Science Can Offer a Valuable Second Opinion on Nature's Plastic Malady.
James BD, Hahn ME, Reddy CM (2022)
Environ Sci Technol. 56(3): 1475-1477.

The aryl hydrocarbon receptor: a predominant mediator for the toxicity of emerging dioxin-like compounds.
Zhang W, Xie HQ, Li Y, Zhou M, Zhou Z, Wang R, Hahn ME, Zhao B (2022)
Journal of Hazardous Materials 426: 128084 (


Developmental exposure to domoic acid disrupts startle response behavior and circuitry in zebrafish.
Panlilio, J. M., Jones, I. T., Salanga, M. C., Aluru, N. and Hahn, M. E. (2021)
Toxicological Sciences 182(2): 310–326

Developmental exposure to domoic acid disrupts startle response behavior and circuitry.
Panlilio, J. M., Jones, I. T., Salanga, M. C., Aluru, N. and Hahn, M. E. (2021)

[see preLight (highlight) of this preprint by Kirsten Sadler and Patrice Delaney on the Company of Biologists web site.]

Alan Poland, MS, MD:  1940-2020.  Poisons as Probes of Biological Function.
Avilla, M.N., Bradfield, C.A., Glover, E., Hahn, M.E., Malecki, K.M.C., Stern, P.H. and Wilson, R.H. (2021).
Chemical Research in Toxicology 34:1-4.

PCB126 Exposure Revealed Alterations in m6A RNA Modifications in Transcripts Associated With AHR Activation
Aluru, N. and Karchner, S. I. (2021).
Toxicol Sci  179, 84-94, 10.1093/toxsci/kfaa158.


Human Health and Ocean Pollution
Landrigan PJ, Stegeman JJ, Fleming LE, Allemand D, Anderson DM, Backer LC, Brucker-Davis F, Chevalier N, Corra L, Czerucka D, Bottein M-YD, Demeneix B, Depledge M, Deheyn DD, Dorman CJ, Fénichel PP, Fisher S, Gaill F, Galgani F, Gaze WH, Giuliano L, Grandjean P, Hahn ME, Hamdoun A, Hess P, Judson B, Laborde A, McGlade J, Mu J, Mustapha A, Neira M, Noble RT, Pedrotti ML, Reddy C, Rocklöv J, Scharler UM, Shanmugam H, Taghian G, Water JAJMvd, Vezzulli L, Weihe P, Zeka A, Raps H, Rampal P (2020)
Annals of Global Health 86(1): 1–64.

A Review of the Functional Roles of the Zebrafish Aryl Hydrocarbon Receptors.
Shankar, P., Dasgupta, S., Hahn, M. E. and Tanguay, R. L. (2020).
Toxicological Sciences 178(2): 215-238. (PMCID: PMC7706399)

Developmental neurotoxicity of the harmful algal bloom toxin domoic acid: Cellular and molecular mechanisms underlying altered behavior in the zebrafish model.
Panlilio JM, Aluru N, Hahn ME (2020)
Environmental Health Perspectives 128: 117002.  (PMCID: PMC7641300)
[See EHP's Science Selection highlight of our paper: Schmidt S (2020) Developmental Neurotoxicity of Domoic Acid: Evidence for a Critical Window of Exposure. Environmental Health Perspectives 128: 124002] [See also selection as one of NIEHS's papers of the month.]

The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model.
Avilla MN, Malecki KMC, Hahn ME, Wilson RH, Bradfield CA (2020)
Chemical Research in Toxicology 33:860−879. (PMCID: PMC7175458)

An Aryl Hydrocarbon Receptor from the Caecilian Amphibian Gymnopis multiplicataSuggests Low Dioxin Affinity in the Ancestor of All Three Amphibian Orders.
Kazzaz SA, Tagliabue SG, Franks DG, Denison MS, Hahn ME, Bonati L, Powell WH (2020)
General and Comparative Endocrinology 299: 113592.

Tributyltin disrupts fin development in Fundulus heteroclitusfrom both PCB-sensitive and resistant populations: Investigations of potential interactions between AhR and PPARγ.
Crawford KA, Clark BW, Heiger-Bernays WJ, Karchner SI, Hahn ME, Nacci DE, Schlezinger JJ (2020)
Aquatic Toxicology 218:105334. PMCID: PMC6935467

Molecular and Functional Properties of the Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a.
Aranguren-Abadia L, Lille-Langoy R, Madsen AK, Karchner SI, Franks DG, Yadetie F, Hahn ME, Goksoyr A, Karlsen OA (2020)
Environ Sci Technol 54:1033-1044. PMCID: PMC7003535

Casting a wide net: use of diverse model organisms to advance toxicology.
Hahn ME, Sadler KC (2020)
Dis Model Mech 13: dmm043844.  PMCID: PMC7132827

Developmental Exposure to PCB153 (2,2',4,4',5,5'-Hexachlorobiphenyl) Alters Circadian Rhythms and the Expression of Clock and Metabolic Genes.
Aluru, N., Krick, K. S., McDonald, A. M. and Karchner, S. I. (2020)
Toxicol Sci 173, 41-52, 10.1093/toxsci/kfz217.


Evolutionary concepts can benefit both fundamental research and applied research in toxicology (A comment on Brady et al. 2017).
Hahn, M. E.(2019)
Evolutionary Applications 12:350–352. PMCID: PMC6346646

Developmental Regulation of Nuclear Factor Erythroid-2 Related Factors (nrfs) by AHR1b in zebrafish (Danio rerio).
Ulin, A., Henderson, J., Pham, M.-T., Meyo, J., Chen, Y., Karchner, S. I., Goldstone, J. V., Hahn, M. E. and Williams, L. M. (2019).
Toxicol Sci 167: 536–545. ( PMCID: PMC6358246

Aryl Hydrocarbon Receptor-Mediated Activity of Gas-Phase Ambient Air Derived from Passive Sampling and an In Vitro Bioassay.
McDonough CA, Franks DG, Hahn ME, Lohmann R (2019)
Environmental Toxicology and Chemistry 38:748–759. PMCID: PMC6467651.

Altered lipid homeostasis in a PCB-resistant Atlantic killifish (Fundulus heteroclitus) population from New Bedford Harbor, MA, U.S.A. 
Crawford KA, Clark BW, Heiger-Bernays WJ, Karchner SI, Henn BGC, Griffith KN, Howes BL, Schlezinger DR, Hahn ME, Nacci DE, Schlezinger JJ (2019)
Aquatic Toxicology 210: 30-43. PMCID: PMC6544361

Transcriptomic analysis of Anabas testudineusand its defensive mechanisms in response to persistent organic pollutants exposure.
Zhang W, Xie HQ, Li Y, Jin T, Li J, Xu L, Zhou Z, Zhang S, Ma D, Hahn ME, Zhao B (2019)
Science of the Total Environment 669: 621–630 ( PMCID: PMC6581032

Characterization of the aryl hydrocarbon receptor (AhR) pathway in Anabas testudineusand mechanistic exploration of the reduced sensitivity of AhR2a.
Zhang W, Xie H, Li Y, Zou X, Xu L, Ma D, Li J, Ma Y, Jin T, Hahn ME, Zhao B (2019)
Environmental Science and Technology 53: 12803-12811. PMCID: PMC6832778


Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus.
Lemaire B, Karchner SI, Goldstone JV, Lamb DC, Drazen JC, Rees JF, Hahn ME, Stegeman JJ (2018)
Biochim Biophys Acta 1866: 155-165.  PMCID: PMC5693637

Redox stress and signaling during vertebrate embryonic development: Regulation and responses.
Timme-Laragy AR, Hahn ME, Hansen JM, Rastogi A, Roy MA (2018)
Seminars in Cell and Developmental Biology: 80: 17-28, 10.1016/j.semcdb.2017.09.019. PMCID: PMC5650060.

Role of DNA methylation in altered gene expression patterns in adult zebrafish (Danio rerio) exposed to 3, 3', 4, 4', 5-pentachlorobiphenyl (PCB 126).
Aluru, N., Karchner, S. I., Krick, K. S., Zhu, W. and Liu, J. (2018)
Environmental Epigenetics 4, dvy005, 10.1093/eep/dvy005.


When evolution is the solution to pollution: How chemical complexity and life history traits interact to influence rapid genetic adaptation, with examples from killifish.
Whitehead A, Clark BW, Reid NM, Hahn ME, Nacci D (2017)
Evolutionary Applications: 10: 762-783.

Diversity as Opportunity: Insights from 600 Million Years of AHR Evolution.
Hahn ME, Karchner SI, Merson RR (2017)
Current Opinion in Toxicology 2: 58-73.

Sequence and functional characterization of hypoxia inducible factors, HIF1α, HIF2αa, and HIF3α, from the estuarine fish, Fundulus heteroclitus.
Townley, I. K., S. I. Karchner, E. Skripnikova, T. E. Wiese, M. E. Hahn and B. B. Rees (2017)
American Journal of Physiology--Regulatory, Integrative and Comparative Physiology: 312: R412–R425.

The landscape of extreme genomic variation in the highly adaptable Atlantic killifish.
Reid NM, Jackson CE, Gilbert D, Minx P, Montague MJ, Hampton TH, Helfrich LW, King BL, Nacci D, Aluru N, Karchner SI, Colbourne JK, Hahn ME, Shaw JR, Oleksiak MF, Crawford DL, Warren WC, Whitehead A (2017)
Genome Biology and Evolution 9: 659–676.

The liver transcriptome of suckermouth armoured catfish (Pterygoplichthys anisitsi, Loricariidae): Identification of expansions in defensome gene families.
Parente TE, Moreira DA, Magalhães MGP, Andrade PCCd, Furtado C, Haas B, Stegeman JJ, Hahn ME  (2017)
Mar Pollut Bull 115: 352-361.

The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing embryo.
Sant KE, Hansen JM, Williams LM, Goldstone JV, Stegeman JJ, Hahn ME, Timme-Laragy A (2017
Redox Biology 13:207-218. PMCID: PMC5458767

Characterizing ryanodine receptor and FK506 binding protein 1 isoforms in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population based comparison.
Holland EB, Goldstone JV, Pessah IN, Lorenzana Z, Whitehead A, Reid N, Karchner SI, Hahn ME, Nacci DE, Clark BW, Stegeman JJ (2017)
Aquatic Toxicology 192: 105-115. PMCID: PMC5662517.

Early Life Exposure to Low Levels of AHR Agonist PCB126 (3,3',4,4',5-Pentachlorobiphenyl) Reprograms Gene Expression in Adult Brain.
Aluru, N., Karchner, S. I. and Glazer, L. (2017)
Toxicol Sci 160, 386-397, 10.1093/toxsci/kfx192.


The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish.
Reid NM, Proestou DA, Clark BW, Warren WC, Colbourne JK, Shaw JR, Karchner SI, Hahn ME, Nacci D, Oleksiak MF, Crawford DL, Whitehead A (2016)
Science 354: 1305-1308.

Integrating monitoring and genetic methods to infer historical risks of PCB and DDE to Common and Roseate Terns nesting near the New Bedford Harbor Superfund site (Massachusetts, USA).
Nacci D, Hahn ME, Karchner SI, Jayaraman S, Mostello C, Miller KM, Blackwell CG, Nisbet I (2016)
Environ Sci Technol 50: 10226-10235.

Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner.
Wincent E, Kubota A, Timme-Laragy A, Jönsson ME, Hahn ME, Stegeman JJ (2016)
Biochemical Pharmacology: 110-111: 117-129.

Delayed effects of developmental exposure to low levels of the aryl hydrocarbon receptor agonist 3,3’,4,4’,5-pentachlorobiphenyl (PCB126) on adult zebrafish behavior.
Glazer, L., Hahn, M.E., Aluru, N.
NeuroToxicology 52: 134-143.


Nrf2 and Nrf2-Related Proteins in Development and Developmental Toxicity:  Insights from studies in Zebrafish (Danio rerio)
Hahn, M.E., Timme-Laragy, A.R., Karchner, S.I., Stegeman, J.J.
Free Radical Biology & Medicine 88: 275-289.

Regulation of Ahr signaling by Nrf2 during development: Effects of Nrf2a deficiency on PCB126 embryotoxicity in zebrafish (Danio rerio)
Rousseau, M.E., Sant, K.E., Borden, L.R., Franks, D.G., Hahn, M.E., Timme-Laragy, A.R.
Aquat Toxicol, 167: 157-171. 

Naturally-Occurring Marine Brominated Indoles are Aryl Hydrocarbon Receptor Ligands/Agonists
DeGroot, D.E., Franks, D.G., Higa, T., Tanaka, J., Hahn, M.E., Denison, M.S.,
Chemical Research in Toxicology28: 1176–1185

An Aryl Hydrocarbon Receptor from the Salamander Ambystoma mexicanum Exhibits Low Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin.
Shoots, J., Fraccalvieri, D., Franks, D.G., Denison, M.S., Hahn, M.E., Bonati, L., Powell, W.H.
Environmental Science and Technology, 49 (11): 6993–7001.

Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor.
Gräns, J., Wassmur, B., Fernández-Santoscoy, M., Zanette, J., Woodin, B.R., Karchner, S.I., Nacci, D.E., Champlin, D., Jayaraman, S., Hahn, M.E., Stegeman, J.J., Celander, M.C., 2014.
Aquat Toxicol, 159: 198-207.

Targeted mutagenesis of aryl hydrocarbon receptor 2a and 2b genes in Atlantic killifish (Fundulus heteroclitus).
Aluru, N., Karchner, S.I., Franks, D.G., Nacci, D., Champlin, D., Hahn, M.E. (2015) 
Aquat Toxicol, 158: 192-201.


The Transcriptional Response to Oxidative Stress During Vertebrate Development: Effects of tert-Butylhydroquinone and 2,3,7,8-Tetrachlorodibenzo-p-dioxin.
Hahn, M.E., McArthur, A.G., Karchner, S.I., Franks, D.G., Jenny, M.J., Timme-Laragy, A.R., Stegeman, J.J., Woodin, B.R., Cipriano, M.J., Linney, E. (2014) 
PLoS ONE 9, e113158. doi:113110.111371/journal.pone.0113158.

Knock-down of a zebrafish aryl hydrocarbon receptor repressor (ahrra) affects transcription of genes related to photoreceptor development and hematopoiesis.
Aluru, N., Jenny, M.J., Hahn, M.E. (2014)
Toxicol Sci, 139: 381-395.

In Silico Identification of an Aryl Hydrocarbon Receptor (AHR) Antagonist with Biological Activity In Vitro and In Vivo.
Parks, A.J., Pollastri, M.P., Hahn, M.E., Stanford, E.A., Novikov, O., Franks, D.G., Haigh, S.E., Narasimhan, S., Ashton, T.D., Hopper, T.G., Kozakov, D., Beglov, D., Vajda, S., Schlezinger, J.J., Sherr, D.H. (2014)
Mol Pharmacol 86, 593–608.

Species-specific relative AHR1 binding affinities of 2,3,4,7,8-pentachlorodibenzofuran explain avian species differences in its relative potency.
Farmahin, R., Jones, S. P., Crump, D., Hahn, M. E., Giesy, J. P., Zwiernik, M. J., Bursian, S. J., and Kennedy, S. W. (2014).
Comp Biochem Physiol C Toxicol Pharmacol  161: 21-25.

Aryl hydrocarbon receptor (AHR) in the cnidarian Nematostella vectensis: comparative expression, protein interactions, and ligand binding.
Reitzel, A. M., Passamaneck, Y. J., Karchner, S. I., Franks, D. G., Martindale, M. Q., Tarrant, A. M., and Hahn, M. E. (2014). 
Development Genes and Evolution, 224(1):13-24

Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production.
Lowe, M. M., Mold, J. E., Kanwar, B., Huang, Y., Louie, A., Pollastri, M. P., Wang, C., Franks, D. G., Schlezinger, J., Sherr, D., Silverstone, A. E., Hahn, M. E., and McCune, J. M. (2014). 
PLoS ONE 9(2): e87877. doi:10.1371/journal.pone.0087877.

Genetic Variation at Aryl Hydrocarbon Receptor (AHR) Loci in populations of Atlantic Killifish (Fundulus heteroclitus) inhabiting Polluted and Reference Habitats.
Reitzel, A. M., Karchner, S. I., Franks, D. G., Evans, B. R., Nacci, D. E., Champlin, D., Vieira, V. M., and Hahn, M. E. (2014). 
BMC Evolutionary Biology14:6.      (WHOI News Release)


Developmental exposure to valproic acid alters the expression of microRNAs involved in neurodevelopment in zebrafish.
Aluru, N., Deak, K. L., Jenny, M. J., and Hahn, M. E. (2013).
Neurotoxicology and Teratology 40, 46-58.

The African coelacanth genome provides insights into tetrapod evolution.
Amemiya, C. T., et al. (2013).
Nature 496, 311-316.
Oceanus article

Functional Characterization of a Full Length Pregnane-X-Receptor, Expression in vivo, and Identification of PXR Alleles in Zebrafish (Danio rerio).
Bainy, A. C. D., Kubota, A., Goldstone, J. V., Lille-Langøy, R., Karchner, S. I., Celander, M. C., Hahn, M. E., Goksøyr, A., and Stegeman, J. J. (2013).
Aquat Toxicol 142-143, 447-457.

Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo.
Timme-Laragy, A. R., Goldstone, J. V., Imhoff, B. R., Stegeman, J. J., Hahn, M. E., and Hansen, J. M. (2013).
Free Radical Biology & Medicine 65C, 89-101.

Developmental expression of the Nfe2-related factor (Nrf) transcription factor family.
Williams, L. M., Timme-Laragy, A. R., Goldstone, J. V., McArthur, A. G., Stegeman, J. J., Smolowitz, R. M., and Hahn, M. E. (2013).
PLoS ONE 8, e79574.

Specific Ligand Binding Domain Residues Confer Low Dioxin Responsiveness to AHR1β of Xenopus laevis.
Odio C, Holzman SA, Denison MS, Fraccalvieri D, Bonati L, Franks DG, Hahn ME, Powell WH (2013)
Biochemistry: 52, 1746−1754.

Comparative Analysis of Homology Models of the Ah Receptor Ligand Binding Domain: Verification of Structure-Function Predictions by Site-Directed Mutagenesis  of a Non-Functional AHR.
Fraccalvieri, D., Soshilov, A. A., Karchner, S. I., Franks, D. G., Pandini, A., Bonati, L., Hahn, M. E., and Denison, M. S. (2013).
Biochemistry 52(4): 714–725.

Differential sensitivity to pro-oxidant exposure in two populations of killifish (Fundulus heteroclitus).
Harbeitner, R. C., Hahn, M. E., and Timme-Laragy, A. R. (2013).
Ecotoxicology, 22, 387–401 (doi:10.1007/s10646-10012-11033-x)

Amino Acid Sequence of the Ligand Binding Domain of the Aryl Hydrocarbon Receptor 1 (AHR1) Predicts Sensitivity of Wild Birds to Effects of Dioxin-like Compounds. 
Farmahin, R., Manning, G., Crump, D., Wu, D., Mundy, L., Jones, S., Hahn, M. E., Karchner, S., Giesy, J., Bursian, S., Zwiernik, M. J., Fredricks, T., and Kennedy, S. (2013).
Toxicol Sci131: 139-152.


Effects of Short-Term Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin on MicroRNA Expression in Zebrafish Embryos. 
Jenny, M. J., Aluru, N., and Hahn, M. E. (2012).
Toxicol Appl Pharmacol, 264: 262–273.

Sequence and In Vitro Function of Chicken, Ring-Necked Pheasant, and Japanese Quail AHR1 Predict In Vivo Sensitivity to Dioxins.
Farmahin, R., Wu, D., Crump, D., Herve, J. C., Jones, S. P., Hahn, M. E., Karchner, S. I., Giesy, J. P., Bursian, S. J., Zwiernik, M. J., and Kennedy, S. W. (2012).
Environ. Sci. Technol. 46, 2967-2975.

Nrf2b: a novel zebrafish paralog of the oxidant-responsive transcription factor NF-E2-related factor 2 (Nrf2).
Timme-Laragy, A. R., Karchner, S. I., Franks, D. G., Jenny, M. J., Harbeitner, R. C., Goldstone, J. V., McArthur, A. G., and Hahn, M. E. (2012).
J. Biol. Chem. 287: 4609-4627.  

Structural and Functional Diversification of AHRs during Metazoan Evolution.
Hahn, M. E. and Karchner, S. I.
Chapter 27.   In The Ah receptor in Biology and Toxicology (R. Pohjanvirta, Ed.). John Wiley & Sons, Inc.

Gene knockdown by morpholino-modified oligonucleotides in the zebrafish model: applications for developmental toxicology.
Timme-Laragy, A. R., Karchner, S. I., and Hahn, M. E.
In Methods in Molecular Biology: Developmental Toxicology (J. M. Hansen, and C. Harris, Eds.). Humana Press.


Mechanistic Research in Aquatic Toxicology: Perspectives and Future Directions
Hahn, M. E.
Aquat Toxicol  105S, 67-71.  (doi:10.1016/j.aquatox.2011.1006.1001)

Transcriptomic assessment of resistance to effects of an aryl hydrocarbon receptor (AHR) agonist in embryos of Atlantic Killifish (Fundulus heteroclitus) from a Marine Superfund Site.
Oleksiak, M. F., Karchner, S. I., Jenny, M. J., Franks, D. G., Mark Welch, D. B., and Hahn, M. E. 
BMC Genomics
12, 263.

Reduced cytochrome P4501A activity and recovery from oxidative stress during subchronic benzo[a]pyrene and benzo[e]pyrene treatment of rainbow trout.
Curtis, L. R., Garzon, C. B., Arkoosh, M., Collier, T., Myers, M. S., Buzitis, J., and Hahn, M. E.
Toxicol Appl Pharmacol254(1), 1-7.

Mechanistic Basis of Resistance to PCBs in Atlantic Tomcod from the Hudson River.
Wirgin, I., Roy, N. K., Loftus, M., Chambers, R. C., Franks, D. G., and Hahn, M. E.
Science 331, 1322-1325 (DOI: 1310.1126/science.1197296).

Role of DNA methylation of AHR1 and AHR2 promoters in differential sensitivity to PCBs in Atlantic Killifish, Fundulus heteroclitus.
Aluru N, Karchner SI, Hahn ME (2011)
Aquat Toxicol.  101(1): 288-94.    PMID: 21111492


Cytochrome P450 diversity and induction by gorgonian allelochemicals in the marine gastropod Cyphoma gibbosum.

Whalen KE, Starczak VR, Nelson DR, Goldstone JV, Hahn ME.

BMC Ecol. 2010 Dec 1;10(1):24.   PMID: 21122142

Developing tools for risk assessment in protected species: Relative potencies inferred from competitive binding of halogenated aromatic hydrocarbons to aryl hydrocarbon receptors from beluga (Delphinapterus leucas) and mouse.

Jensen BA, Reddy CM, Nelson RK, Hahn ME.

Aquat Toxicol. 2010 Nov 1;100(3):238-45. Epub 2010 Jul 23.    PMID: 20728228


Estrogen responses in killifish (Fundulus heteroclitus) from polluted and unpolluted environments are site- and gene-specific.

Greytak SR, Tarrant AM, Nacci D, Hahn ME, Callard GV.

Aquat Toxicol. 2010 Aug 15;99(2):291-9. Epub 2010 May 19.    PMID: 20570371


The role of multixenobiotic transporters in predatory marine molluscs as counter-defense mechanisms against dietary allelochemicals.

Whalen KE, Sotka EE, Goldstone JV, Hahn ME.

Comp Biochem Physiol C Toxicol Pharmacol. 2010 Sep;152(3):288-300. Epub 2010 May 21.    PMID: 20546934


Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists.

Howard GJ, Schlezinger JJ, Hahn ME, Webster TF.

Environ Health Perspect. 2010 May;118(5):666-72.   PMID: 20435555  Free PMC Article


Brominated flame retardants and organochlorine contaminants in winter flounder, harp and hooded seals, and North Atlantic right whales from the Northwest Atlantic Ocean.

Montie EW, Letcher RJ, Reddy CM, Moore MJ, Rubinstein B, Hahn ME.

Mar Pollut Bull. 2010 Aug;60(8):1160-9.   PMID: 20434733


Biochemical warfare on the reef: the role of glutathione transferases in consumer tolerance of dietary prostaglandins.

Whalen KE, Lane AL, Kubanek J, Hahn ME.

PLoS One. 2010 Jan 6;5(1):e8537.   PMID: 20052279  Free PMC Article



The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) binds multiple AHRs and induces multiple CYP1 genes via AHR2 in zebrafish.

Jonsson ME, Franks DG, Woodin BR, Jenny MJ, Garrick RA, Behrendt L, Hahn ME, Stegeman JJ.

Chem Biol Interact. 2009 Oct 30;181(3):447-54. Epub 2009 Jul 15.   PMID: 19615353  Free PMC Article


Interaction of fish aryl hydrocarbon receptor paralogs (AHR1 and AHR2) with the retinoblastoma protein.

Merson RR, Karchner SI, Hahn ME.

Aquat Toxicol. 2009 Aug 13;94(1):47-55. Epub 2009 Jun 2.   PMID: 19539383  Free PMC Article


Distinct roles of two zebrafish AHR repressors (AHRRa and AHRRb) in embryonic development and regulating the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Jenny MJ, Karchner SI, Franks DG, Woodin BR, Stegeman JJ, Hahn ME.

Toxicol Sci. 2009 Aug;110(2):426-41. Epub 2009 Jun 3.   PMID: 19494032  Free PMC Article


The active form of human aryl hydrocarbon receptor (AHR) repressor lacks exon 8, and its Pro 185 and Ala 185 variants repress both AHR and hypoxia-inducible factor.

Karchner SI, Jenny MJ, Tarrant AM, Evans BR, Kang HJ, Bae I, Sherr DH, Hahn ME.

Mol Cell Biol. 2009 Jul;29(13):3465-77. Epub 2009 Apr 20.   PMID: 19380484   Free PMC Article


Organohalogen contaminants and metabolites in cerebrospinal fluid and cerebellum gray matter in short-beaked common dolphins and Atlantic white-sided dolphins from the western North Atlantic.

Montie EW, Reddy CM, Gebbink WA, Touhey KE, Hahn ME, Letcher RJ.

Environ Pollut. 2009 Aug-Sep;157(8-9):2345-58. Epub 2009 Apr 17.   PMID: 19375836


Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor.

Hahn ME, Allan LL, Sherr DH.

Biochem Pharmacol. 2009 Feb 15;77(4):485-97. Epub 2008 Sep 20. Review.   PMID: 18848529   Free PMC Article



Key amino acids in the aryl hydrocarbon receptor predict dioxin sensitivity in avian species.

Head JA, Hahn ME, Kennedy SW.

Environ Sci Technol. 2008 Oct 1;42(19):7535-41.   PMID: 18939598


Proteomic identification, cDNA cloning and enzymatic activity of glutathione S-transferases from the generalist marine gastropod, Cyphoma gibbosum.

Whalen KE, Morin D, Lin CY, Tjeerdema RS, Goldstone JV, Hahn ME.

Arch Biochem Biophys. 2008 Oct 1;478(1):7-17. Epub 2008 Jul 17.   PMID: 18671936


Development of the morpholino gene knockdown technique in Fundulus heteroclitus: a tool for studying molecular mechanisms in an established environmental model.

Matson CW, Clark BW, Jenny MJ, Fleming CR, Hahn ME, Di Giulio RT.

Aquat Toxicol. 2008 May 30;87(4):289-95. Epub 2008 Feb 23.   PMID: 18378331 Free PMC Article


Volumetric neuroimaging of the atlantic white-sided dolphin (Lagenorhynchus acutus) brain from in situ magnetic resonance images.

Montie EW, Schneider G, Ketten DR, Marino L, Touhey KE, Hahn ME.

Anat Rec (Hoboken). 2008 Mar;291(3):263-82.   PMID: 18286607  Free Article


Cytochrome P4501A1 expression, polychlorinated biphenyls and hydroxylated metabolites, and adipocyte size of bottlenose dolphins from the Southeast United States.

Montie EW, Fair PA, Bossart GD, Mitchum GB, Houde M, Muir DC, Letcher RJ, McFee WE, Starczak VR, Stegeman JJ, Hahn ME.

Aquat Toxicol. 2008 Feb 18;86(3):397-412. Epub 2007 Dec 23.   PMID: 18222549


Blubber morphology in wild bottlenose dolphins (Tursiops truncatus) from the Southeastern United States: influence of geographic location, age class, and reproductive state.

Montie EW, Garvin SR, Fair PA, Bossart GD, Mitchum GB, McFee WE, Speakman T, Starczak VR, Hahn ME.

J Morphol. 2008 Apr;269(4):496-511.   PMID: 18157858


Functional properties of the four Atlantic salmon (Salmo salar) aryl hydrocarbon receptor type 2 (AHR2) isoforms.

Hansson MC, Hahn ME.

Aquat Toxicol. 2008 Jan 31;86(2):121-30. Epub 2007 Nov 1.   PMID: 18063141  Free PMC Article


Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator.

Evans BR, Karchner SI, Allan LL, Pollenz RS, Tanguay RL, Jenny MJ, Sherr DH, Hahn ME.

Mol Pharmacol. 2008 Feb;73(2):387-98. Epub 2007 Nov 13.   PMID: 18000031 Free Article



Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics.

Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, Gómez-Chiarri M, Hahn ME, Hoover CA, Karchner SI, Katoh F, Maclatchy DL, Marshall WS, Meyer JN, Nacci DE, Oleksiak MF, Rees BB, Singer TD, Stegeman JJ, Towle DW, Van Veld PA, Vogelbein WK, Whitehead A, Winn RN, Crawford DL.

Comp Biochem Physiol Part D Genomics Proteomics. 2007 Dec;2(4):257-86.   PMID: 18071578  Free PMC Article


Fish models in toxicology.

Carvan MJ 3rd, Gallagher EP, Goks√∏yr A, Hahn ME, Larsson DG.

Zebrafish. 2007 Spring;4(1):9-20. No abstract available.    PMID: 18041939


Neuroanatomy of the subadult and fetal brain of the Atlantic white-sided dolphin (Lagenorhynchus acutus) from in situ magnetic resonance images.

Montie EW, Schneider GE, Ketten DR, Marino L, Touhey KE, Hahn ME.

Anat Rec (Hoboken). 2007 Dec;290(12):1459-79.   PMID: 17957751  Free Article


Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Jonsson ME, Jenny MJ, Woodin BR, Hahn ME, Stegeman JJ.

Toxicol Sci. 2007 Nov;100(1):180-93. Epub 2007 Aug 8.   PMID: 17686920  Free Article


Functional characterization and evolutionary history of two aryl hydrocarbon receptor isoforms (AhR1 and AhR2) from avian species.

Yasui T, Kim EY, Iwata H, Franks DG, Karchner SI, Hahn ME, Tanabe S.

Toxicol Sci. 2007 Sep;99(1):101-17. Epub 2007 Jun 7.   PMID: 17556759  Free Article



The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome.

Goldstone JV, Hamdoun A, Cole BJ, Howard-Ashby M, Nebert DW, Scally M, Dean M, Epel D, Hahn ME, Stegeman JJ.

Dev Biol. 2006 Dec 1;300(1):366-84. Epub 2006 Sep 3.   PMID: 17097629


The genome of the sea urchin Strongylocentrotus purpuratus.

Sea Urchin Genome Sequencing Consortium, Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P , Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Bell é R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Genevière AM, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K , Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallböök F, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C, Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Röttinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R.

Science. 2006 Nov 10;314(5801):941-52. Erratum in: Science. 2007 Feb 9;315(5813):766.    PMID: 17095691 Free Article


Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomics.

Hahn ME, Karchner SI, Evans BR, Franks DG, Merson RR, Lapseritis JM.

J Exp Zool A Comp Exp Biol. 2006 Sep 1;305(9):693-706. Review.   PMID: 16902966


Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness.

Tarrant AM, Greytak SR, Callard GV, Hahn ME.

J Mol Endocrinol. 2006 Aug;37(1):105-20.   PMID: 16901928  Free Article


The molecular basis for differential dioxin sensitivity in birds: role of the aryl hydrocarbon receptor.

Karchner SI, Franks DG, Kennedy SW, Hahn ME.

Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6252-7. Epub 2006 Apr 10.   PMID: 16606854  Free PMC Article


Development and characterization of polyclonal antibodies against the aryl hydrocarbon receptor protein family (AHR1, AHR2, and AHR repressor) of Atlantic killifish Fundulus heteroclitus.

Merson RR, Franks DG, Karchner SI, Hahn ME.

Comp Biochem Physiol C Toxicol Pharmacol. 2006 Jan-Feb;142(1-2):85-94. Epub 2005 Dec 20.   PMID: 16364694



Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: structure, function, evolution, and AHR-dependent regulation in vivo.

Evans BR, Karchner SI, Franks DG, Hahn ME.

Arch Biochem Biophys. 2005 Sep 15;441(2):151-67.   PMID: 16122694


The aryl hydrocarbon receptor constitutively represses c-myc transcription in human mammary tumor cells.

Yang X, Liu D, Murray TJ, Mitchell GC, Hesterman EV, Karchner SI, Merson RR, Hahn ME, Sherr DH.

Oncogene. 2005 Nov 24;24(53):7869-81.   PMID: 16091746


AHR1B, a new functional aryl hydrocarbon receptor in zebrafish: tandem arrangement of ahr1b and ahr2 genes.

Karchner SI, Franks DG, Hahn ME.

Biochem J. 2005 Nov 15;392(Pt 1):153-61.   PMID: 16042621  Free PMC Article


Biological activity and physicochemical parameters of marine halogenated natural products 2,3,3',4,4',5,5'-heptachloro-1'-methyl-1,2'-bipyrrole and 2,4,6-tribromoanisole.

Vetter W, Hahn ME, Tomy G, Ruppe S, Vatter S, Chahbane N, Lenoir D, Schramm KW, Scherer G.

Arch Environ Contam Toxicol. 2005 Jan;48(1):1-9.   PMID: 15657799   



Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V alcohol dehydrogenase genes but have distinct functional characteristics.

Reimers MJ, Hahn ME, Tanguay RL.

J Biol Chem. 2004 Sep 10;279(37):38303-12. Epub 2004 Jul 1.   PMID: 15231826  Free Article


Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus).

Powell WH, Morrison HG, Weil EJ, Karchner SI, Sogin ML, Stegeman JJ, Hahn ME.

Mar Environ Res. 2004 Aug-Dec;58(2-5):119-24.   PMID: 15178023   


Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus).

Hahn ME, Karchner SI, Franks DG, Merson RR.

Pharmacogenetics. 2004 Feb;14(2):131-43.   PMID: 15077014   



Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories.

Meyer JN, Wassenberg DM, Karchner SI, Hahn ME, Di Giulio RT.

Environ Toxicol Chem. 2003 Oct;22(10):2337-43.   PMID: 14551997   


Naturally produced halogenated dimethyl bipyrroles bind to the aryl hydrocarbon receptor and induce cytochrome P4501A and porphyrin accumulation in chicken embryo hepatocytes.

Tittlemier SA, Kennedy SW, Hahn ME, Reddy CM, Norstrom RJ.

Environ Toxicol Chem. 2003 Jul;22(7):1622-31.   PMID: 12836989   


Gonadal feminization and halogenated environmental contaminants in common terns (Sterna hirundo): evidence that ovotestes in male embryos do not persist to the prefledgling stage.

Hart CA, Nisbet IC, Kennedy SW, Hahn ME.

Ecotoxicology. 2003 Feb-Aug;12(1-4):125-40.   PMID: 12739862   



A ligand for the aryl hydrocarbon receptor isolated from lung.

Song J, Clagett-Dame M, Peterson RE, Hahn ME, Westler WM, Sicinski RR, DeLuca HF.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14694-9. Epub 2002 Oct 30.   PMID: 12409613  Free PMC ArticleFree text


cDNA cloning of an aryl hydrocarbon receptor from Baikal seals (Phoca sibirica).

Kim EY, Hahn ME, Iwata H, Tanabe S, Miyazaki N.

Mar Environ Res. 2002 Sep-Dec;54(3-5):285-9.   PMID: 12408578   


Binding of polycyclic aromatic hydrocarbons (PAHs) to teleost aryl hydrocarbon receptors (AHRs).

Billiard SM, Hahn ME, Franks DG, Peterson RE, Bols NC, Hodson PV.

Comp Biochem Physiol B Biochem Mol Biol. 2002 Sep;133(1):55-68.   PMID: 12223212   


Aryl hydrocarbon receptors: diversity and evolution.

Hahn ME.

Chem Biol Interact. 2002 Sep 20;141(1-2):131-60. Review.   PMID: 12213389   


The zebrafish (Danio rerio) aryl hydrocarbon receptor type 1 is a novel vertebrate receptor.

Andreasen EA, Hahn ME, Heideman W, Peterson RE, Tanguay RL.

Mol Pharmacol. 2002 Aug;62(2):234-49.   PMID: 12130674  Free Article


Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics.

Bard SM, Bello SM, Hahn ME, Stegeman JJ.

Aquat Toxicol. 2002 Sep 24;59(3-4):237-51.   PMID: 12127740   


cDNA cloning and characterization of an aryl hydrocarbon receptor from the harbor seal (Phoca vitulina): a biomarker of dioxin susceptibility?

Kim EY, Hahn ME.

Aquat Toxicol. 2002 Jul;58(1-2):57-73.   PMID: 12062155   


Biomarkers and bioassays for detecting dioxin-like compounds in the marine environment.

Hahn ME.

Sci Total Environ. 2002 Apr 22;289(1-3):49-69. Review.   PMID: 12049406   


Relationships among the cell cycle, cell proliferation, and aryl hydrocarbon receptor expression in PLHC-1 cells.

Hestermann EV, Stegeman JJ, Hahn ME.

Aquat Toxicol. 2002 Aug;58(3-4):201-13.   PMID: 12007875   


Serum withdrawal leads to reduced aryl hydrocarbon receptor expression and loss of cytochrome P4501A inducibility in PLHC-1 cells.

Hestermann EV, Stegeman JJ, Hahn ME.

Biochem Pharmacol. 2002 Apr 15;63(8):1405-14.   PMID: 11996881   


Identification and functional characterization of hypoxia-inducible factor 2alpha from the estuarine teleost, Fundulus heteroclitus: interaction of HIF-2alpha with two ARNT2 splice variants.

Powell WH, Hahn ME.

J Exp Zool. 2002 Apr 15;294(1):17-29.   PMID: 11932946   


Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2.

Karchner SI, Franks DG, Powell WH, Hahn ME.

J Biol Chem. 2002 Mar 1;277(9):6949-59. Epub 2001 Dec 12.   PMID: 11742002  Free Article



Dioxin toxicology and the aryl hydrocarbon receptor: insights from fish and other non-traditional models.

Hahn ME.

Mar Biotechnol (NY). 2001 Jun;3(Supplement 1):S224-38.   PMID: 14961319 [PubMed]


An aryl hydrocarbon receptor (AHR) homologue from the soft-shell clam, Mya arenaria: evidence that invertebrate AHR homologues lack 2,3,7,8-tetrachlorodibenzo-p-dioxin and beta-naphthoflavone binding.

Butler RA, Kelley ML, Powell WH, Hahn ME, Van Beneden RJ.

Gene. 2001 Oct 31;278(1-2):223-34.   PMID: 11707340   


cDNA cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, Delphinapterus leucas.

Jensen BA, Hahn ME.

Toxicol Sci. 2001 Nov;64(1):41-56.   PMID: 11606800  Free Article


2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos.

Toomey BH, Bello S, Hahn ME, Cantrell S, Wright P, Tillitt DE, Di Giulio RT.

Aquat Toxicol. 2001 Jul;53(2):127-38.   PMID: 11311389   


Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: in vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes.

Bello SM, Franks DG, Stegeman JJ, Hahn ME.

Toxicol Sci. 2001 Mar;60(1):77-91.   PMID: 11222875  Free Article



In vitro metabolism of polychlorinated biphenyl congeners by beluga whale (Delphinapterus leucas) and pilot whale (Globicephala melas) and relationship to cytochrome P450 expression.

White RD, Shea D, Schlezinger JJ, Hahn ME, Stegeman JJ.

Comp Biochem Physiol C Toxicol Pharmacol. 2000 Jul;126(3):267-84.   PMID: 11048677   


Towards molecular understanding of species differences in dioxin sensitivity: initial characterization of Ah receptor cDNAs in birds and an amphibian.

Karchner SI, Kennedy SW, Trudeau S, Hahn ME.

Mar Environ Res. 2000 Jul-Dec;50(1-5):51-6.   PMID: 11460741   


The evolution of aryl hydrocarbon signaling proteins: diversity of ARNT isoforms among fish species.

Powell WH, Hahn ME.

Mar Environ Res. 2000 Jul-Dec;50(1-5):39-44.   PMID: 11460724   


Relative contributions of affinity and intrinsic efficacy to aryl hydrocarbon receptor ligand potency.

Hestermann EV, Stegeman JJ, Hahn ME.

Toxicol Appl Pharmacol. 2000 Oct 15;168(2):160-72.   PMID: 11032772   


Developmental and tissue-specific expression of AHR1, AHR2, and ARNT2 in dioxin-sensitive and -resistant populations of the marine fish Fundulus heteroclitus.

Powell WH, Bright R, Bello SM, Hahn ME.

Toxicol Sci. 2000 Oct;57(2):229-39.   PMID: 11006353  Free Article


The bioflavonoid galangin blocks aryl hydrocarbon receptor activation and polycyclic aromatic hydrocarbon-induced pre-B cell apoptosis.

Quadri SA, Qadri AN, Hahn ME, Mann KK, Sherr DH.

Mol Pharmacol. 2000 Sep;58(3):515-25.   PMID: 10953044  Free Article


Serum alters the uptake and relative potencies of halogenated aromatic hydrocarbons in cell culture bioassays.

Hestermann EV, Stegeman JJ, Hahn ME.

Toxicol Sci. 2000 Feb;53(2):316-25.   PMID: 10696780  Free Article



Identification and functional characterization of two highly divergent aryl hydrocarbon receptors (AHR1 and AHR2) in the teleost Fundulus heteroclitus. Evidence for a novel subfamily of ligand-binding basic helix loop helix-Per-ARNT-Sim (bHLH-PAS) factors.

Karchner SI, Powell WH, Hahn ME.

J Biol Chem. 1999 Nov 19;274(47):33814-24.   PMID: 10559277  Free Article


The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenz[a]anthracene-induced pre-B lymphocyte apoptosis.

Mann KK, Matulka RA, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH.

Toxicol Appl Pharmacol. 1999 Nov 15;161(1):10-22.   PMID: 10558919   


Cytochrome P4501A induction and porphyrin accumulation in PLHC-1 fish cells exposed to sediment and oil shale extracts.

Huuskonen SE, Tuvikene A, Trapido M, Fent K, Hahn ME.

Arch Environ Contam Toxicol. 2000 Jan;38(1):59-69.   PMID: 10556372   


Two forms of aryl hydrocarbon receptor type 2 in rainbow trout (Oncorhynchus mykiss). Evidence for differential expression and enhancer specificity.

Abnet CC, Tanguay RL, Hahn ME, Heideman W, Peterson RE.

J Biol Chem. 1999 May 21;274(21):15159-66.   PMID: 10329723  Free PMC ArticleFree text


The aryl hydrocarbon receptor: a comparative perspective.

Hahn ME.

Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):23-53. Review.   PMID: 9972449   


Functional diversity of vertebrate ARNT proteins: identification of ARNT2 as the predominant form of ARNT in the marine teleost, Fundulus heteroclitus.

Powell WH, Karchner SI, Bright R, Hahn ME.

Arch Biochem Biophys. 1999 Jan 1;361(1):156-63.   PMID: 9882441   


Aryl hydrocarbon receptor function in early vertebrates: inducibility of cytochrome P450 1A in agnathan and elasmobranch fish.

Hahn ME, Woodin BR, Stegeman JJ, Tillitt DE.

Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Jul;120(1):67-75.   PMID: 9827018   


A fish hepatoma cell line (PLHC-1) as a tool to study cytotoxicity and CYP1A induction properties of cellulose and wood chip extracts.

Huuskonen SE, Hahn ME, Lindström-Seppä P.

Chemosphere. 1998 Jun;36(14):2921-32.   PMID: 9734273   


Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): characterization of the Ah receptor and the role of CYP1A inhibition.

Besselink HT, Denison MS, Hahn ME, Karchner SI, Vethaak AD, Koeman JH, Brouwer A.

Toxicol Sci. 1998 Jun;43(2):161-71.   PMID: 9710958   


Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family.

Hahn ME, Karchner SI, Shapiro MA, Perera SA.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13743-8.   PMID: 9391097  Free PMC ArticleFree text


Halogenated aromatic hydrocarbon-mediated porphyrin accumulation and induction of cytochrome P4501A in chicken embryo hepatocytes.

Lorenzen A, Kennedy SW, Bastien LJ, Hahn ME.

Biochem Pharmacol. 1997 Feb 7;53(3):373-84.   PMID: 9065741   

Cytochrome P4501A induction in avian hepatocyte cultures: a promising approach for predicting the sensitivity of avian species to toxic effects of halogenated aromatic hydrocarbons.

Kennedy SW, Lorenzen A, Jones SP, Hahn ME, Stegeman JJ.

Toxicol Appl Pharmacol. 1996 Nov;141(1):214-30.   PMID: 8917694   


Uroporphyrin accumulation associated with cytochrome P4501A induction in fish hepatoma cells exposed to aryl hydrocarbon receptor agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and planar chlorobiphenyls.

Hahn ME, Chandran K.

Arch Biochem Biophys. 1996 May 15;329(2):163-74.   PMID: 8638948   


Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A.

Celander M, Hahn ME, Stegeman JJ.

Arch Biochem Biophys. 1996 May 1;329(1):113-22.   PMID: 8619627   


Evolutionary conservation of the vertebrate Ah (dioxin) receptor: amplification and sequencing of the PAS domain of a teleost Ah receptor cDNA.

Hahn ME, Karchner SI.

Biochem J. 1995 Sep 1;310 ( Pt 2):383-7.   PMID: 7654172  Free PMC ArticleFree text


Induction of cytochrome P4501A1 by aryl hydrocarbon receptor agonists in porcine aorta endothelial cells in culture and cytochrome P4501A1 activity in intact cells.

Stegeman JJ, Hahn ME, Weisbrod R, Woodin BR, Joy JS, Najibi S, Cohen RA.

Mol Pharmacol. 1995 Feb;47(2):296-306.   PMID: 7870038   


Regulation of cytochrome P4501A1 in teleosts: sustained induction of CYP1A1 mRNA, protein, and catalytic activity by 2,3,7,8-tetrachlorodibenzofuran in the marine fish Stenotomus chrysops.

Hahn ME, Stegeman JJ.

Toxicol Appl Pharmacol. 1994 Aug;127(2):187-98.   PMID: 8048062   


Catalytic and immunochemical characterization of hepatic microsomal cytochromes P450 in beluga whale (Delphinapterus leucas).

White RD, Hahn ME, Lockhart WL, Stegeman JJ.

Toxicol Appl Pharmacol. 1994 May;126(1):45-57.   PMID: 8184432   


Photoaffinity labeling of the Ah receptor: phylogenetic survey of diverse vertebrate and invertebrate species.

Hahn ME, Poland A, Glover E, Stegeman JJ.

Arch Biochem Biophys. 1994 Apr;310(1):218-28.   PMID: 8161208   


Immunohistochemical localization of environmentally induced cytochrome P450IA1 in multiple organs of the marine teleost Stenotomus chrysops (Scup).

Stegeman JJ, Smolowitz RM, Hahn ME.

Toxicol Appl Pharmacol. 1991 Sep 15;110(3):486-504.   PMID: 1949016   


Determination of individual porphyrins in rodent urine using high-performance liquid chromatography following clean-up by anion-exchange chromatography.

Hahn ME, Gasiewicz TA.

J Chromatogr. 1991 Feb 15;563(2):363-8.   PMID: 2056000   


Immunohistochemical localization of cytochrome P-450IA1 induced by 3,3',4,4'-tetrachlorobiphenyl and by 2,3,7,8-tetrachlorodibenzoafuran in liver and extrahepatic tissues of the teleost Stenotomus chrysops (scup).

Smolowitz RM, Hahn ME, Stegeman JJ.

Drug Metab Dispos. 1991 Jan-Feb;19(1):113-23.   PMID: 1708328   


Effects of ortho- and non-ortho-substituted polychlorinated biphenyl congeners on the hepatic monooxygenase system in scup (Stenotomus chrysops).

Gooch JW, Elskus AA, Kloepper-Sams PJ, Hahn ME, Stegeman JJ.

Toxicol Appl Pharmacol. 1989 May;98(3):422-33.   PMID: 2497554   


Interaction of hexachlorobenzene with the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro and in vivo. Evidence that hexachlorobenzene is a weak Ah receptor agonist.

Hahn ME, Goldstein JA, Linko P, Gasiewicz TA.

Arch Biochem Biophys. 1989 Apr;270(1):344-55.   PMID: 2539049   


The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice.

Hahn ME, Gasiewicz TA, Linko P, Goldstein JA.

Biochem J. 1988 Aug 15;254(1):245-54.   PMID: 2845946  Free PMC ArticleFree text


Structure-activity relationships of chlorinated benzenes as inducers of hepatic cytochrome P-450 isozymes in the rat.

Goldstein JA, Linko P, Hahn ME, Gasiewicz TA, Yeowell HN.

IARC Sci Publ. 1986;(77):519-26.   PMID: 3596751

Highlighted publications

  • Developmental neurotoxicity of the harmful algal bloom toxin domoic acid: Cellular and molecular mechanisms underlying altered behavior in the zebrafish model.
    Panlilio JM, Aluru N, Hahn ME (2020)
    Environmental Health Perspectives128: 117002. ( (PMCID: PMC7641300)
  • Human Health and Ocean Pollution
    Landrigan et al. (2020)
    Annals of Global Health 86(1): 1–64.
  • A Review of the Functional Roles of the Zebrafish Aryl Hydrocarbon Receptors. 
    Shankar, P., Dasgupta, S., Hahn, M. E.and Tanguay, R. L. (2020).
    Toxicol Sci, 178(2):215-238. ( (PMCID: PMC7706399)

Read more

  • The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model. 
    Avilla MN, Malecki KMC, Hahn ME, Wilson RH, Bradfield CA (2020)
    Chem Res Toxicol 33:860−879. ( (PMCID: PMC7175458)
  • Diversity as Opportunity: Insights from 600 Million Years of AHR Evolution.
    Hahn ME, Karchner SI, Merson RR (2017)
    Current Opinion in Toxicology 2: 58-73.
  • The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish.
    Reid NM, Proestou DA, Clark BW, Warren WC, Colbourne JK, Shaw JR, Karchner SI, Hahn ME, Nacci D, Oleksiak MF, Crawford DL, Whitehead A (2016)
    Science 354: 1305-1308.